Owen DJ - Search Results

1

Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models.

Kaminskas LM, McLeod VM, Kelly BD, Cullinane C, Sberna G, Williamson M, Boyd BJ, Owen DJ, Porter CJ. Kaminskas LM, et al. Among authors: owen dj. Mol Pharm. 2012 Mar 5;9(3):422-32. doi: 10.1021/mp200522d. Epub 2012 Jan 27. Mol Pharm. 2012. PMID: 22233281

2

Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers.

Kaminskas LM, Kelly BD, McLeod VM, Sberna G, Boyd BJ, Owen DJ, Porter CJ. Kaminskas LM, et al. Among authors: owen dj. Mol Pharm. 2011 Apr 4;8(2):338-49. doi: 10.1021/mp1001872. Epub 2011 Jan 21. Mol Pharm. 2011. PMID: 21171585

3

Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker.

Kaminskas LM, Kelly BD, McLeod VM, Sberna G, Owen DJ, Boyd BJ, Porter CJ. Kaminskas LM, et al. Among authors: owen dj. J Control Release. 2011 Jun 10;152(2):241-8. doi: 10.1016/j.jconrel.2011.02.005. Epub 2011 Feb 21. J Control Release. 2011. PMID: 21315119

4

A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems.

Kaminskas LM, McLeod VM, Kelly BD, Sberna G, Boyd BJ, Williamson M, Owen DJ, Porter CJ. Kaminskas LM, et al. Among authors: owen dj. Nanomedicine. 2012 Jan;8(1):103-11. doi: 10.1016/j.nano.2011.05.013. Epub 2011 Jun 23. Nanomedicine. 2012. PMID: 21704192

5

Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent.

Ryan GM, Kaminskas LM, Kelly BD, Owen DJ, McIntosh MP, Porter CJ. Ryan GM, et al. Among authors: owen dj. Mol Pharm. 2013 Aug 5;10(8):2986-95. doi: 10.1021/mp400091n. Epub 2013 Jun 26. Mol Pharm. 2013. PMID: 23750747

6

PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin.

Ryan GM, Kaminskas LM, Bulitta JB, McIntosh MP, Owen DJ, Porter CJH. Ryan GM, et al. Among authors: owen dj. J Control Release. 2013 Nov 28;172(1):128-136. doi: 10.1016/j.jconrel.2013.08.004. Epub 2013 Aug 13. J Control Release. 2013. PMID: 23954628

7

Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy.

Kaminskas LM, McLeod VM, Ryan GM, Kelly BD, Haynes JM, Williamson M, Thienthong N, Owen DJ, Porter CJ. Kaminskas LM, et al. Among authors: owen dj. J Control Release. 2014 Jun 10;183:18-26. doi: 10.1016/j.jconrel.2014.03.012. Epub 2014 Mar 14. J Control Release. 2014. PMID: 24637466

8

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.

Kaminskas LM, McLeod VM, Ascher DB, Ryan GM, Jones S, Haynes JM, Trevaskis NL, Chan LJ, Sloan EK, Finnin BA, Williamson M, Velkov T, Williams ED, Kelly BD, Owen DJ, Porter CJ. Kaminskas LM, et al. Among authors: owen dj. Mol Pharm. 2015 Feb 2;12(2):432-43. doi: 10.1021/mp500531e. Epub 2015 Jan 20. Mol Pharm. 2015. PMID: 25485615

9

A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep.

Ryan GM, Bischof RJ, Enkhbaatar P, McLeod VM, Chan LJ, Jones SA, Owen DJ, Porter CJ, Kaminskas LM. Ryan GM, et al. Among authors: owen dj. Pharm Res. 2016 Feb;33(2):510-25. doi: 10.1007/s11095-015-1806-z. Epub 2015 Oct 20. Pharm Res. 2016. PMID: 26486513

10

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers.

Haque S, McLeod VM, Jones S, Fung S, Whittaker M, McIntosh M, Pouton C, Owen DJ, Porter CJH, Kaminskas LM. Haque S, et al. Among authors: owen dj. Eur J Pharm Biopharm. 2017 Oct;119:408-418. doi: 10.1016/j.ejpb.2017.07.005. Epub 2017 Jul 13. Eur J Pharm Biopharm. 2017. PMID: 28713018

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