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Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.
Hahn S, Brüning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik CU, Bulic B, Weggen S. Hahn S, et al. Among authors: baches s. J Neurochem. 2011 Feb;116(3):385-95. doi: 10.1111/j.1471-4159.2010.07118.x. Epub 2010 Dec 13. J Neurochem. 2011. PMID: 21091478 Free article.
Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier.
Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, Pietrzik CU. Storck SE, et al. Among authors: baches s. J Clin Invest. 2016 Jan;126(1):123-36. doi: 10.1172/JCI81108. Epub 2015 Nov 30. J Clin Invest. 2016. PMID: 26619118 Free PMC article.