Pietrzik CU - Search Results

1

Presenilin is the molecular target of acidic γ-secretase modulators in living cells.

Jumpertz T, Rennhack A, Ness J, Baches S, Pietrzik CU, Bulic B, Weggen S. Jumpertz T, et al. Among authors: pietrzik cu. PLoS One. 2012;7(1):e30484. doi: 10.1371/journal.pone.0030484. Epub 2012 Jan 6. PLoS One. 2012. PMID: 22238696 Free PMC article.

2

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.

Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. Weggen S, et al. Among authors: pietrzik cu. Nature. 2001 Nov 8;414(6860):212-6. doi: 10.1038/35102591. Nature. 2001. PMID: 11700559

3

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing.

Pietrzik CU, Busse T, Merriam DE, Weggen S, Koo EH. Pietrzik CU, et al. EMBO J. 2002 Nov 1;21(21):5691-700. doi: 10.1093/emboj/cdf568. EMBO J. 2002. PMID: 12411487 Free PMC article.

4

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo EH. Weggen S, et al. Among authors: pietrzik cu. J Biol Chem. 2003 Aug 15;278(33):30748-54. doi: 10.1074/jbc.M304824200. Epub 2003 May 31. J Biol Chem. 2003. PMID: 12777371 Free article.

5

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.

Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH. Weggen S, et al. Among authors: pietrzik cu. J Biol Chem. 2003 Aug 22;278(34):31831-7. doi: 10.1074/jbc.M303592200. Epub 2003 Jun 12. J Biol Chem. 2003. PMID: 12805356 Free article.

6

FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

Pietrzik CU, Yoon IS, Jaeger S, Busse T, Weggen S, Koo EH. Pietrzik CU, et al. J Neurosci. 2004 Apr 28;24(17):4259-65. doi: 10.1523/JNEUROSCI.5451-03.2004. J Neurosci. 2004. PMID: 15115822 Free PMC article.

7

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S. Leuchtenberger S, et al. Among authors: pietrzik cu. J Neurochem. 2006 Jan;96(2):355-65. doi: 10.1111/j.1471-4159.2005.03553.x. Epub 2005 Nov 21. J Neurochem. 2006. PMID: 16300630 Free article.

8

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S. Czirr E, et al. Among authors: pietrzik cu. J Biol Chem. 2007 Aug 24;282(34):24504-13. doi: 10.1074/jbc.M700618200. Epub 2007 Jun 15. J Biol Chem. 2007. PMID: 17573346 Free article.

9

The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors.

Martin AM, Kuhlmann C, Trossbach S, Jaeger S, Waldron E, Roebroek A, Luhmann HJ, Laatsch A, Weggen S, Lessmann V, Pietrzik CU. Martin AM, et al. Among authors: pietrzik cu. J Biol Chem. 2008 May 2;283(18):12004-13. doi: 10.1074/jbc.M707607200. Epub 2008 Mar 5. J Biol Chem. 2008. PMID: 18321860 Free article.

10

Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein.

Leuchtenberger S, Maler J, Czirr E, Ness J, Lichtenthaler SF, Esselmann H, Pietrzik CU, Wiltfang J, Weggen S. Leuchtenberger S, et al. Among authors: pietrzik cu. Neurodegener Dis. 2009;6(1-2):1-8. doi: 10.1159/000121391. Epub 2008 Mar 18. Neurodegener Dis. 2009. PMID: 18349521

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