Savva R - Search Results

1

Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting.

Meier C, Brookings DC, Ceska TA, Doyle C, Gong H, McMillan D, Saville GP, Mushtaq A, Knight D, Reich S, Pearl LH, Powell KA, Savva R, Allen RA. Meier C, et al. Among authors: savva r. J Struct Biol. 2012 Feb;177(2):329-34. doi: 10.1016/j.jsb.2012.01.002. Epub 2012 Jan 8. J Struct Biol. 2012. PMID: 22245778

2

Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high-throughput applications.

Reich S, Puckey LH, Cheetham CL, Harris R, Ali AA, Bhattacharyya U, Maclagan K, Powell KA, Prodromou C, Pearl LH, Driscoll PC, Savva R. Reich S, et al. Among authors: savva r. Protein Sci. 2006 Oct;15(10):2356-65. doi: 10.1110/ps.062082606. Protein Sci. 2006. PMID: 17008718 Free PMC article.

3

Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex.

Savva R, Pearl LH. Savva R, et al. Nat Struct Biol. 1995 Sep;2(9):752-7. doi: 10.1038/nsb0995-752. Nat Struct Biol. 1995. PMID: 7552746

4

Crystallization and preliminary X-ray analysis of the uracil-DNA glycosylase DNA repair enzyme from herpes simplex virus type 1.

Savva R, Pearl LH. Savva R, et al. J Mol Biol. 1993 Dec 5;234(3):910-2. doi: 10.1006/jmbi.1993.1642. J Mol Biol. 1993. PMID: 8254688

5

The problem with pyrimidines.

Pearl LH, Savva R. Pearl LH, et al. Among authors: savva r. Nat Struct Biol. 1996 Jun;3(6):485-7. doi: 10.1038/nsb0696-485. Nat Struct Biol. 1996. PMID: 8646528 No abstract available.

6

A combinatorial method to enable detailed investigation of protein-protein interactions.

Maclagan K, Tommasi R, Laurine E, Prodromou C, Driscoll PC, Pearl LH, Reich S, Savva R. Maclagan K, et al. Among authors: savva r. Future Med Chem. 2011 Mar;3(3):271-82. doi: 10.4155/fmc.10.289. Future Med Chem. 2011. PMID: 21446842

7

Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct.

Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH. Barrett TE, et al. Among authors: savva r. Nat Struct Biol. 1998 Aug;5(8):697-701. doi: 10.1038/1394. Nat Struct Biol. 1998. PMID: 9699633

8

Cloning and expression of the uracil-DNA glycosylase inhibitor (UGI) from bacteriophage PBS-1 and crystallization of a uracil-DNA glycosylase-UGI complex.

Savva R, Pearl LH. Savva R, et al. Proteins. 1995 Jul;22(3):287-9. doi: 10.1002/prot.340220310. Proteins. 1995. PMID: 7479702

9

Direct measurement of the substrate preference of uracil-DNA glycosylase.

Panayotou G, Brown T, Barlow T, Pearl LH, Savva R. Panayotou G, et al. Among authors: savva r. J Biol Chem. 1998 Jan 2;273(1):45-50. doi: 10.1074/jbc.273.1.45. J Biol Chem. 1998. PMID: 9417045 Free article.

The residues aspartic acid-88 and histidine-210, implicated in the catalytic mechanism of the enzyme (Savva, R., McAuley-Hecht, K., Brown, T., and Pearl, L. (1995) Nature 373, 487-493; Slupphaug, G., Mol, C. ...

The residues aspartic acid-88 and histidine-210, implicated in the catalytic mechanism of the enzyme (Savva, R., McAuley-Hecht …

10

Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions.

Barrett TE, Savva R, Panayotou G, Barlow T, Brown T, Jiricny J, Pearl LH. Barrett TE, et al. Among authors: savva r. Cell. 1998 Jan 9;92(1):117-29. doi: 10.1016/s0092-8674(00)80904-6. Cell. 1998. PMID: 9489705 Free article.

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