Kaku T - Search Results

1

Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys.

Yamaoka M, Hara T, Hitaka T, Kaku T, Takeuchi T, Takahashi J, Asahi S, Miki H, Tasaka A, Kusaka M. Yamaoka M, et al. Among authors: kaku t. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):115-28. doi: 10.1016/j.jsbmb.2012.01.001. Epub 2012 Jan 12. J Steroid Biochem Mol Biol. 2012. PMID: 22249003

2

17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.

Kaku T, Tsujimoto S, Matsunaga N, Tanaka T, Hara T, Yamaoka M, Kusaka M, Tasaka A. Kaku T, et al. Bioorg Med Chem. 2011 Apr 1;19(7):2428-42. doi: 10.1016/j.bmc.2011.02.009. Epub 2011 Feb 12. Bioorg Med Chem. 2011. PMID: 21429754

3

Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer.

Kaku T, Hitaka T, Ojida A, Matsunaga N, Adachi M, Tanaka T, Hara T, Yamaoka M, Kusaka M, Okuda T, Asahi S, Furuya S, Tasaka A. Kaku T, et al. Bioorg Med Chem. 2011 Nov 1;19(21):6383-99. doi: 10.1016/j.bmc.2011.08.066. Epub 2011 Sep 1. Bioorg Med Chem. 2011. PMID: 21978946

4

Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats.

Hara T, Kouno J, Kaku T, Takeuchi T, Kusaka M, Tasaka A, Yamaoka M. Hara T, et al. Among authors: kaku t. J Steroid Biochem Mol Biol. 2013 Mar;134:80-91. doi: 10.1016/j.jsbmb.2012.10.020. Epub 2012 Nov 9. J Steroid Biochem Mol Biol. 2013. PMID: 23146910

5

Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys.

Yamaoka M, Hara T, Araki H, Kaku T, Hitaka T, Tasaka A, Kusaka M. Yamaoka M, et al. Among authors: kaku t. J Steroid Biochem Mol Biol. 2013 Nov;138:298-306. doi: 10.1016/j.jsbmb.2013.07.002. Epub 2013 Jul 12. J Steroid Biochem Mol Biol. 2013. PMID: 23856460

6

C17,20-lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors.

Matsunaga N, Kaku T, Itoh F, Tanaka T, Hara T, Miki H, Iwasaki M, Aono T, Yamaoka M, Kusaka M, Tasaka A. Matsunaga N, et al. Among authors: kaku t. Bioorg Med Chem. 2004 May 1;12(9):2251-73. doi: 10.1016/j.bmc.2004.02.007. Bioorg Med Chem. 2004. PMID: 15080924

7

C(17,20)-lyase inhibitors. Part 2: design, synthesis and structure-activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C(17,20)-lyase inhibitors.

Matsunaga N, Kaku T, Ojida A, Tanaka T, Hara T, Yamaoka M, Kusaka M, Tasaka A. Matsunaga N, et al. Among authors: kaku t. Bioorg Med Chem. 2004 Aug 15;12(16):4313-36. doi: 10.1016/j.bmc.2004.06.016. Bioorg Med Chem. 2004. PMID: 15265485

8

17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors.

Kaku T, Matsunaga N, Ojida A, Tanaka T, Hara T, Yamaoka M, Kusaka M, Tasaka A. Kaku T, et al. Bioorg Med Chem. 2011 Mar 1;19(5):1751-70. doi: 10.1016/j.bmc.2011.01.017. Epub 2011 Jan 15. Bioorg Med Chem. 2011. PMID: 21316976

9

Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists.

Yamamoto S, Tomita N, Suzuki Y, Suzaki T, Kaku T, Hara T, Yamaoka M, Kanzaki N, Hasuoka A, Baba A, Ito M. Yamamoto S, et al. Among authors: kaku t. Bioorg Med Chem. 2012 Apr 1;20(7):2338-52. doi: 10.1016/j.bmc.2012.02.005. Epub 2012 Feb 10. Bioorg Med Chem. 2012. PMID: 22391033

10

Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists.

Yamamoto S, Kobayashi H, Kaku T, Aikawa K, Hara T, Yamaoka M, Kanzaki N, Hasuoka A, Baba A, Ito M. Yamamoto S, et al. Among authors: kaku t. Bioorg Med Chem. 2013 Jan 1;21(1):70-83. doi: 10.1016/j.bmc.2012.11.001. Epub 2012 Nov 12. Bioorg Med Chem. 2013. PMID: 23199477

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