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mRNA knockdown by single strand RNA is improved by chemical modifications.
Haringsma HJ, Li JJ, Soriano F, Kenski DM, Flanagan WM, Willingham AT. Haringsma HJ, et al. Among authors: kenski dm. Nucleic Acids Res. 2012 May;40(9):4125-36. doi: 10.1093/nar/gkr1301. Epub 2012 Jan 16. Nucleic Acids Res. 2012. PMID: 22253019 Free PMC article.
Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.
Kenski DM, Cooper AJ, Li JJ, Willingham AT, Haringsma HJ, Young TA, Kuklin NA, Jones JJ, Cancilla MT, McMasters DR, Mathur M, Sachs AB, Flanagan WM. Kenski DM, et al. Nucleic Acids Res. 2010 Jan;38(2):660-71. doi: 10.1093/nar/gkp913. Epub 2009 Nov 16. Nucleic Acids Res. 2010. PMID: 19917641 Free PMC article.
siRNA-optimized Modifications for Enhanced In Vivo Activity.
Kenski DM, Butora G, Willingham AT, Cooper AJ, Fu W, Qi N, Soriano F, Davies IW, Flanagan WM. Kenski DM, et al. Mol Ther Nucleic Acids. 2012 Jan 24;1(1):e5. doi: 10.1038/mtna.2011.4. Mol Ther Nucleic Acids. 2012. PMID: 23344622 Free PMC article.
Nucleoside optimization for RNAi: a high-throughput platform.
Butora G, Kenski DM, Cooper AJ, Fu W, Qi N, Li JJ, Flanagan WM, Davies IW. Butora G, et al. Among authors: kenski dm. J Am Chem Soc. 2011 Oct 26;133(42):16766-9. doi: 10.1021/ja2068774. Epub 2011 Sep 30. J Am Chem Soc. 2011. PMID: 21942264
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.
Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S. Jaiswal BS, et al. Among authors: kenski dm. Cancer Cell. 2009 Dec 8;16(6):463-74. doi: 10.1016/j.ccr.2009.10.016. Cancer Cell. 2009. PMID: 19962665 Free PMC article.
17 results