Harding HP - Search Results

1

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.

Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D, Harding HP. Cross BC, et al. Among authors: harding hp. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78. doi: 10.1073/pnas.1115623109. Epub 2012 Feb 6. Proc Natl Acad Sci U S A. 2012. PMID: 22315414 Free PMC article.

2

Cloning of mammalian Ire1 reveals diversity in the ER stress responses.

Wang XZ, Harding HP, Zhang Y, Jolicoeur EM, Kuroda M, Ron D. Wang XZ, et al. Among authors: harding hp. EMBO J. 1998 Oct 1;17(19):5708-17. doi: 10.1093/emboj/17.19.5708. EMBO J. 1998. PMID: 9755171 Free PMC article.

3

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase.

Harding HP, Zhang Y, Ron D. Harding HP, et al. Nature. 1999 Jan 21;397(6716):271-4. doi: 10.1038/16729. Nature. 1999. PMID: 9930704

4

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. Urano F, et al. Among authors: harding hp. Science. 2000 Jan 28;287(5453):664-6. doi: 10.1126/science.287.5453.664. Science. 2000. PMID: 10650002

5

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response.

Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Bertolotti A, et al. Among authors: harding hp. Nat Cell Biol. 2000 Jun;2(6):326-32. doi: 10.1038/35014014. Nat Cell Biol. 2000. PMID: 10854322

6

Perk is essential for translational regulation and cell survival during the unfolded protein response.

Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. Harding HP, et al. Mol Cell. 2000 May;5(5):897-904. doi: 10.1016/s1097-2765(00)80330-5. Mol Cell. 2000. PMID: 10882126 Free article.

7

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha.

Novoa I, Zeng H, Harding HP, Ron D. Novoa I, et al. Among authors: harding hp. J Cell Biol. 2001 May 28;153(5):1011-22. doi: 10.1083/jcb.153.5.1011. J Cell Biol. 2001. PMID: 11381086 Free PMC article.

8

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.

Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D. Calfon M, et al. Among authors: harding hp. Nature. 2002 Jan 3;415(6867):92-6. doi: 10.1038/415092a. Nature. 2002. PMID: 11780124

9

Transcriptional and translational control in the Mammalian unfolded protein response.

Harding HP, Calfon M, Urano F, Novoa I, Ron D. Harding HP, et al. Annu Rev Cell Dev Biol. 2002;18:575-99. doi: 10.1146/annurev.cellbio.18.011402.160624. Epub 2002 Apr 2. Annu Rev Cell Dev Biol. 2002. PMID: 12142265 Review.

10

Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.

Kimball SR, Horetsky RL, Ron D, Jefferson LS, Harding HP. Kimball SR, et al. Among authors: harding hp. Am J Physiol Cell Physiol. 2003 Feb;284(2):C273-84. doi: 10.1152/ajpcell.00314.2002. Epub 2002 Oct 3. Am J Physiol Cell Physiol. 2003. PMID: 12388085 Free article.

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