Sproul D - Search Results

1

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression.

Latham T, Mackay L, Sproul D, Karim M, Culley J, Harrison DJ, Hayward L, Langridge-Smith P, Gilbert N, Ramsahoye BH. Latham T, et al. Among authors: sproul d. Nucleic Acids Res. 2012 Jun;40(11):4794-803. doi: 10.1093/nar/gks066. Epub 2012 Feb 9. Nucleic Acids Res. 2012. PMID: 22323521 Free PMC article.

2

Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatin that reflect nucleosome organisation.

Kerr L, Kafetzopoulos I, Grima R, Sproul D. Kerr L, et al. Among authors: sproul d. PLoS Genet. 2023 Oct 2;19(10):e1010958. doi: 10.1371/journal.pgen.1010958. eCollection 2023 Oct. PLoS Genet. 2023. PMID: 37782664 Free PMC article.

3

The role of chromatin structure in regulating the expression of clustered genes.

Sproul D, Gilbert N, Bickmore WA. Sproul D, et al. Nat Rev Genet. 2005 Oct;6(10):775-81. doi: 10.1038/nrg1688. Nat Rev Genet. 2005. PMID: 16160692 Review.

4

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.

Eskeland R, Leeb M, Grimes GR, Kress C, Boyle S, Sproul D, Gilbert N, Fan Y, Skoultchi AI, Wutz A, Bickmore WA. Eskeland R, et al. Among authors: sproul d. Mol Cell. 2010 May 14;38(3):452-64. doi: 10.1016/j.molcel.2010.02.032. Mol Cell. 2010. PMID: 20471950 Free PMC article.

5

Analysis of active and inactive X chromosome architecture reveals the independent organization of 30 nm and large-scale chromatin structures.

Naughton C, Sproul D, Hamilton C, Gilbert N. Naughton C, et al. Among authors: sproul d. Mol Cell. 2010 Nov 12;40(3):397-409. doi: 10.1016/j.molcel.2010.10.013. Mol Cell. 2010. PMID: 21070966 Free PMC article.

6

Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.

Sproul D, Nestor C, Culley J, Dickson JH, Dixon JM, Harrison DJ, Meehan RR, Sims AH, Ramsahoye BH. Sproul D, et al. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4364-9. doi: 10.1073/pnas.1013224108. Epub 2011 Feb 28. Proc Natl Acad Sci U S A. 2011. PMID: 21368160 Free PMC article.

7

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.

Nestor CE, Ottaviano R, Reddington J, Sproul D, Reinhardt D, Dunican D, Katz E, Dixon JM, Harrison DJ, Meehan RR. Nestor CE, et al. Among authors: sproul d. Genome Res. 2012 Mar;22(3):467-77. doi: 10.1101/gr.126417.111. Epub 2011 Nov 21. Genome Res. 2012. PMID: 22106369 Free PMC article.

8

Diversity of matriptase expression level and function in breast cancer.

Welman A, Sproul D, Mullen P, Muir M, Kinnaird AR, Harrison DJ, Faratian D, Brunton VG, Frame MC. Welman A, et al. Among authors: sproul d. PLoS One. 2012;7(4):e34182. doi: 10.1371/journal.pone.0034182. Epub 2012 Apr 13. PLoS One. 2012. PMID: 22514623 Free PMC article.

9

Targeting of Rac GTPases blocks the spread of intact human breast cancer.

Katz E, Sims AH, Sproul D, Caldwell H, Dixon MJ, Meehan RR, Harrison DJ. Katz E, et al. Among authors: sproul d. Oncotarget. 2012 Jun;3(6):608-19. doi: 10.18632/oncotarget.520. Oncotarget. 2012. PMID: 22689141 Free PMC article.

10

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns.

Sproul D, Kitchen RR, Nestor CE, Dixon JM, Sims AH, Harrison DJ, Ramsahoye BH, Meehan RR. Sproul D, et al. Genome Biol. 2012 Oct 3;13(10):R84. doi: 10.1186/gb-2012-13-10-r84. Genome Biol. 2012. PMID: 23034185 Free PMC article.

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