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Page 1
Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1.
Le Brazidec JY, Pasis A, Tam B, Boykin C, Black C, Wang D, Claassen G, Chong JH, Chao J, Fan J, Nguyen K, Silvian L, Ling L, Zhang L, Choi M, Teng M, Pathan N, Zhao S, Li T, Taveras A. Le Brazidec JY, et al. Among authors: claassen g. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2070-4. doi: 10.1016/j.bmcl.2012.01.019. Epub 2012 Jan 18. Bioorg Med Chem Lett. 2012. PMID: 22326168
Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors.
Le Brazidec JY, Pasis A, Tam B, Boykin C, Wang D, Marcotte DJ, Claassen G, Chong JH, Chao J, Fan J, Nguyen K, Silvian L, Ling L, Zhang L, Choi M, Teng M, Pathan N, Zhao S, Li T, Taveras A. Le Brazidec JY, et al. Among authors: claassen g. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4033-7. doi: 10.1016/j.bmcl.2012.04.085. Epub 2012 Apr 25. Bioorg Med Chem Lett. 2012. PMID: 22607669
Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group.
Sirisoma N, Kasibhatla S, Nguyen B, Pervin A, Wang Y, Claassen G, Tseng B, Drewe J, Cai SX. Sirisoma N, et al. Among authors: claassen g. Bioorg Med Chem. 2006 Dec 1;14(23):7761-73. doi: 10.1016/j.bmc.2006.08.002. Epub 2006 Aug 21. Bioorg Med Chem. 2006. PMID: 16919962
One-week 96-well soft agar growth assay for cancer target validation.
Ke N, Albers A, Claassen G, Yu DH, Chatterton JE, Hu X, Meyhack B, Wong-Staal F, Li QX. Ke N, et al. Among authors: claassen g. Biotechniques. 2004 May;36(5):826-8, 830, 832-3. doi: 10.2144/04365ST07. Biotechniques. 2004. PMID: 15152603 Free article.
22 results