Prabhu S - Search Results

1

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice.

Deng R, Meng YG, Hoyte K, Lutman J, Lu Y, Iyer S, DeForge LE, Theil FP, Fielder PJ, Prabhu S. Deng R, et al. Among authors: prabhu s. MAbs. 2012 Jan-Feb;4(1):101-9. doi: 10.4161/mabs.4.1.18543. MAbs. 2012. PMID: 22327433 Free PMC article.

2

Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies.

Mortensen DL, Prabhu S, Stefanich EG, Kadkhodayan-Fischer S, Gelzleichter TR, Baker D, Jiang J, Wallace K, Iyer S, Fielder PJ, Putnam WS. Mortensen DL, et al. Among authors: prabhu s. MAbs. 2012 Nov-Dec;4(6):724-31. doi: 10.4161/mabs.22216. MAbs. 2012. PMID: 23778267 Free PMC article.

3

A strategy for risk mitigation of antibodies with fast clearance.

Hötzel I, Theil FP, Bernstein LJ, Prabhu S, Deng R, Quintana L, Lutman J, Sibia R, Chan P, Bumbaca D, Fielder P, Carter PJ, Kelley RF. Hötzel I, et al. Among authors: prabhu s. MAbs. 2012 Nov-Dec;4(6):753-60. doi: 10.4161/mabs.22189. MAbs. 2012. PMID: 23778268 Free PMC article.

4

Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor.

Yip V, Palma E, Tesar DB, Mundo EE, Bumbaca D, Torres EK, Reyes NA, Shen BQ, Fielder PJ, Prabhu S, Khawli LA, Boswell CA. Yip V, et al. Among authors: prabhu s. MAbs. 2014 May-Jun;6(3):689-96. doi: 10.4161/mabs.28254. Epub 2014 Feb 26. MAbs. 2014. PMID: 24572100 Free PMC article.

5

An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans.

Chung S, Nguyen V, Lin YL, Lafrance-Vanasse J, Scales SJ, Lin K, Deng R, Williams K, Sperinde G, Li JJ, Zheng K, Sukumaran S, Tesar D, Ernst JA, Fischer S, Lazar GA, Prabhu S, Song A. Chung S, et al. Among authors: prabhu s. MAbs. 2019 Jul;11(5):942-955. doi: 10.1080/19420862.2019.1605270. Epub 2019 Apr 29. MAbs. 2019. PMID: 30982394 Free PMC article.

6

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys.

Deng R, Loyet KM, Lien S, Iyer S, DeForge LE, Theil FP, Lowman HB, Fielder PJ, Prabhu S. Deng R, et al. Among authors: prabhu s. Drug Metab Dispos. 2010 Apr;38(4):600-5. doi: 10.1124/dmd.109.031310. Epub 2010 Jan 13. Drug Metab Dispos. 2010. PMID: 20071453 Clinical Trial.

7

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

Deng R, Iyer S, Theil FP, Mortensen DL, Fielder PJ, Prabhu S. Deng R, et al. Among authors: prabhu s. MAbs. 2011 Jan-Feb;3(1):61-6. doi: 10.4161/mabs.3.1.13799. Epub 2011 Jan 1. MAbs. 2011. PMID: 20962582 Free PMC article.

8

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.

Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM, Prabhu S, Watts RJ, Dennis MS. Yu YJ, et al. Among authors: prabhu s. Sci Transl Med. 2011 May 25;3(84):84ra44. doi: 10.1126/scitranslmed.3002230. Sci Transl Med. 2011. PMID: 21613623

9

Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?

Deng R, Jin F, Prabhu S, Iyer S. Deng R, et al. Among authors: prabhu s. Expert Opin Drug Metab Toxicol. 2012 Feb;8(2):141-60. doi: 10.1517/17425255.2012.643868. Epub 2012 Jan 17. Expert Opin Drug Metab Toxicol. 2012. PMID: 22248267 Review.

10

Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.

Couch JA, Yu YJ, Zhang Y, Tarrant JM, Fuji RN, Meilandt WJ, Solanoy H, Tong RK, Hoyte K, Luk W, Lu Y, Gadkar K, Prabhu S, Ordonia BA, Nguyen Q, Lin Y, Lin Z, Balazs M, Scearce-Levie K, Ernst JA, Dennis MS, Watts RJ. Couch JA, et al. Among authors: prabhu s. Sci Transl Med. 2013 May 1;5(183):183ra57, 1-12. doi: 10.1126/scitranslmed.3005338. Sci Transl Med. 2013. PMID: 23636093

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