Bischof J - Search Results

1

2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/ε.

Bischof J, Leban J, Zaja M, Grothey A, Radunsky B, Othersen O, Strobl S, Vitt D, Knippschild U. Bischof J, et al. Amino Acids. 2012 Oct;43(4):1577-91. doi: 10.1007/s00726-012-1234-x. Epub 2012 Feb 14. Amino Acids. 2012. PMID: 22331384 Free PMC article.

2

Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1δ and ε with nanomolar inhibitory activity on cancer cell proliferation.

Richter J, Bischof J, Zaja M, Kohlhof H, Othersen O, Vitt D, Alscher V, Pospiech I, García-Reyes B, Berg S, Leban J, Knippschild U. Richter J, et al. Among authors: bischof j. J Med Chem. 2014 Oct 9;57(19):7933-46. doi: 10.1021/jm500600b. Epub 2014 Sep 17. J Med Chem. 2014. PMID: 25191940

3

Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.

Richter J, Ullah K, Xu P, Alscher V, Blatz A, Peifer C, Halekotte J, Leban J, Vitt D, Holzmann K, Bakulev V, Pinna LA, Henne-Bruns D, Hillenbrand A, Kornmann M, Leithäuser F, Bischof J, Knippschild U. Richter J, et al. Among authors: bischof j. Int J Cancer. 2015 Jun 15;136(12):2799-810. doi: 10.1002/ijc.29346. Epub 2014 Dec 1. Int J Cancer. 2015. PMID: 25404202

4

CK1δ activity is modulated by CDK2/E- and CDK5/p35-mediated phosphorylation.

Ianes C, Xu P, Werz N, Meng Z, Henne-Bruns D, Bischof J, Knippschild U. Ianes C, et al. Among authors: bischof j. Amino Acids. 2016 Feb;48(2):579-92. doi: 10.1007/s00726-015-2114-y. Amino Acids. 2016. PMID: 26464264

5

CK1δ kinase activity is modulated by protein kinase C α (PKCα)-mediated site-specific phosphorylation.

Meng Z, Bischof J, Ianes C, Henne-Bruns D, Xu P, Knippschild U. Meng Z, et al. Among authors: bischof j. Amino Acids. 2016 May;48(5):1185-97. doi: 10.1007/s00726-015-2154-3. Epub 2016 Jan 23. Amino Acids. 2016. PMID: 26803658

6

Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo.

Hirner H, Günes C, Bischof J, Wolff S, Grothey A, Kühl M, Oswald F, Wegwitz F, Bösl MR, Trauzold A, Henne-Bruns D, Peifer C, Leithäuser F, Deppert W, Knippschild U. Hirner H, et al. Among authors: bischof j. PLoS One. 2012;7(1):e29709. doi: 10.1371/journal.pone.0029709. Epub 2012 Jan 3. PLoS One. 2012. PMID: 22235331 Free PMC article.

7

CK1δ kinase activity is modulated by Chk1-mediated phosphorylation.

Bischof J, Randoll SJ, Süßner N, Henne-Bruns D, Pinna LA, Knippschild U. Bischof J, et al. PLoS One. 2013 Jul 4;8(7):e68803. doi: 10.1371/journal.pone.0068803. Print 2013. PLoS One. 2013. PMID: 23861943 Free PMC article.

8

Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.

Halekotte J, Witt L, Ianes C, Krüger M, Bührmann M, Rauh D, Pichlo C, Brunstein E, Luxenburger A, Baumann U, Knippschild U, Bischof J, Peifer C. Halekotte J, et al. Among authors: bischof j. Molecules. 2017 Mar 24;22(4):522. doi: 10.3390/molecules22040522. Molecules. 2017. PMID: 28338621 Free PMC article.

9

The kinase domain of CK1δ can be phosphorylated by Chk1.

Böhm T, Meng Z, Haas P, Henne-Bruns D, Rachidi N, Knippschild U, Bischof J. Böhm T, et al. Among authors: bischof j. Biosci Biotechnol Biochem. 2019 Sep;83(9):1663-1675. doi: 10.1080/09168451.2019.1617105. Epub 2019 May 16. Biosci Biotechnol Biochem. 2019. PMID: 31094292

10

Newly Developed CK1-Specific Inhibitors Show Specifically Stronger Effects on CK1 Mutants and Colon Cancer Cell Lines.

Liu C, Witt L, Ianes C, Bischof J, Bammert MT, Baier J, Kirschner S, Henne-Bruns D, Xu P, Kornmann M, Peifer C, Knippschild U. Liu C, et al. Among authors: bischof j. Int J Mol Sci. 2019 Dec 7;20(24):6184. doi: 10.3390/ijms20246184. Int J Mol Sci. 2019. PMID: 31817920 Free PMC article.

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