Tutt A - Search Results

1

BRCA1 testing should be offered to individuals with triple-negative breast cancer diagnosed below 50 years.

Robertson L, Hanson H, Seal S, Warren-Perry M, Hughes D, Howell I, Turnbull C, Houlston R, Shanley S, Butler S, Evans DG, Ross G, Eccles D, Tutt A, Rahman N; TNT Trial TMG; BCSC (UK). Robertson L, et al. Among authors: tutt a. Br J Cancer. 2012 Mar 13;106(6):1234-8. doi: 10.1038/bjc.2012.31. Epub 2012 Feb 14. Br J Cancer. 2012. PMID: 22333603 Free PMC article.

2

Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification.

Tutt A, Gabriel A, Bertwistle D, Connor F, Paterson H, Peacock J, Ross G, Ashworth A. Tutt A, et al. Curr Biol. 1999 Oct 7;9(19):1107-10. doi: 10.1016/s0960-9822(99)80479-5. Curr Biol. 1999. PMID: 10531007 Free article.

3

Commentary: much still to learn about relations between tumour biology, prognosis, and treatment outcome in early breast cancer.

Tutt A, Ross G. Tutt A, et al. BMJ. 2000 Feb 19;320(7233):478-9. BMJ. 2000. PMID: 10722296 No abstract available.

4

Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.

Tutt A, Bertwistle D, Valentine J, Gabriel A, Swift S, Ross G, Griffin C, Thacker J, Ashworth A. Tutt A, et al. EMBO J. 2001 Sep 3;20(17):4704-16. doi: 10.1093/emboj/20.17.4704. EMBO J. 2001. PMID: 11532935 Free PMC article.

5

Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.

Tutt AN, van Oostrom CT, Ross GM, van Steeg H, Ashworth A. Tutt AN, et al. EMBO Rep. 2002 Mar;3(3):255-60. doi: 10.1093/embo-reports/kvf037. Epub 2002 Feb 15. EMBO Rep. 2002. PMID: 11850397 Free PMC article.

6

DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells.

Gudmundsdottir K, Lord CJ, Witt E, Tutt AN, Ashworth A. Gudmundsdottir K, et al. Among authors: tutt an. EMBO Rep. 2004 Oct;5(10):989-93. doi: 10.1038/sj.embor.7400255. Epub 2004 Sep 10. EMBO Rep. 2004. PMID: 15359272 Free PMC article.

7

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.

McCabe N, Lord CJ, Tutt AN, Martin NM, Smith GC, Ashworth A. McCabe N, et al. Among authors: tutt an. Cancer Biol Ther. 2005 Sep;4(9):934-6. doi: 10.4161/cbt.4.9.2141. Epub 2005 Sep 1. Cancer Biol Ther. 2005. PMID: 16251802 Free article.

8

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.

Iorns E, Turner NC, Elliott R, Syed N, Garrone O, Gasco M, Tutt AN, Crook T, Lord CJ, Ashworth A. Iorns E, et al. Among authors: tutt an. Cancer Cell. 2008 Feb;13(2):91-104. doi: 10.1016/j.ccr.2008.01.001. Cancer Cell. 2008. PMID: 18242510 Free article.

9

Novel one-stop multidisciplinary follow-up clinic significantly improves cancer risk management in BRCA1/2 carriers.

Pichert G, Jacobs C, Jacobs I, Menon U, Manchanda R, Johnson M, Hamed H, Firth C, Evison M, Tutt A, de Silva L, Langman C, Izatt L. Pichert G, et al. Among authors: tutt a. Fam Cancer. 2010 Sep;9(3):313-9. doi: 10.1007/s10689-010-9333-x. Fam Cancer. 2010. PMID: 20300867 Free article.

10

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer.

Loi S, Haibe-Kains B, Majjaj S, Lallemand F, Durbecq V, Larsimont D, Gonzalez-Angulo AM, Pusztai L, Symmans WF, Bardelli A, Ellis P, Tutt AN, Gillett CE, Hennessy BT, Mills GB, Phillips WA, Piccart MJ, Speed TP, McArthur GA, Sotiriou C. Loi S, et al. Among authors: tutt an. Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10208-13. doi: 10.1073/pnas.0907011107. Epub 2010 May 17. Proc Natl Acad Sci U S A. 2010. PMID: 20479250 Free PMC article.

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