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Sequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode.
Singh CR, Watanabe R, Chowdhury W, Hiraishi H, Murai MJ, Yamamoto Y, Miles D, Ikeda Y, Asano M, Asano K. Singh CR, et al. Mol Cell Biol. 2012 Oct;32(19):3978-89. doi: 10.1128/MCB.00376-12. Epub 2012 Jul 30. Mol Cell Biol. 2012. PMID: 22851688 Free PMC article.
Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression.
Hiraishi H, Oatman J, Haller SL, Blunk L, McGivern B, Morris J, Papadopoulos E, Gutierrez W, Gordon M, Bokhari W, Ikeda Y, Miles D, Fellers J, Asano M, Wagner G, Tazi L, Rothenburg S, Brown SJ, Asano K. Hiraishi H, et al. Nucleic Acids Res. 2014;42(16):10321-30. doi: 10.1093/nar/gku670. Epub 2014 Aug 21. Nucleic Acids Res. 2014. PMID: 25147208 Free PMC article.
The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β.
Luna RE, Arthanari H, Hiraishi H, Nanda J, Martin-Marcos P, Markus MA, Akabayov B, Milbradt AG, Luna LE, Seo HC, Hyberts SG, Fahmy A, Reibarkh M, Miles D, Hagner PR, O'Day EM, Yi T, Marintchev A, Hinnebusch AG, Lorsch JR, Asano K, Wagner G. Luna RE, et al. Cell Rep. 2012 Jun 28;1(6):689-702. doi: 10.1016/j.celrep.2012.04.007. Epub 2012 May 24. Cell Rep. 2012. PMID: 22813744 Free PMC article.
48 results