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A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.
Bach A, Clausen BH, Møller M, Vestergaard B, Chi CN, Round A, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K. Bach A, et al. Among authors: stromgaard k. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3317-22. doi: 10.1073/pnas.1113761109. Epub 2012 Feb 17. Proc Natl Acad Sci U S A. 2012. PMID: 22343531 Free PMC article.
A sequential binding mechanism in a PDZ domain.
Chi CN, Bach A, Engström A, Wang H, Strømgaard K, Gianni S, Jemth P. Chi CN, et al. Among authors: stromgaard k. Biochemistry. 2009 Aug 4;48(30):7089-97. doi: 10.1021/bi900559k. Biochemistry. 2009. PMID: 19496620
158 results