Alferez D - Search Results

1

The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models.

Holt SV, Logié A, Odedra R, Heier A, Heaton SP, Alferez D, Davies BR, Wilkinson RW, Smith PD. Holt SV, et al. Among authors: alferez d. Br J Cancer. 2012 Feb 28;106(5):858-66. doi: 10.1038/bjc.2012.8. Epub 2012 Feb 16. Br J Cancer. 2012. PMID: 22343622 Free PMC article.

2

Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055).

Holt SV, Logie A, Davies BR, Alferez D, Runswick S, Fenton S, Chresta CM, Gu Y, Zhang J, Wu YL, Wilkinson RW, Guichard SM, Smith PD. Holt SV, et al. Among authors: alferez d. Cancer Res. 2012 Apr 1;72(7):1804-13. doi: 10.1158/0008-5472.CAN-11-1780. Epub 2012 Jan 23. Cancer Res. 2012. PMID: 22271687

3

Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia.

Alferez DG, Goodlad RA, Odedra R, Sini P, Crafter C, Ryan AJ, Wedge SR, Wright NA, Anderson E, Wilkinson RW. Alferez DG, et al. Int J Oncol. 2012 Oct;41(4):1475-85. doi: 10.3892/ijo.2012.1580. Epub 2012 Jul 31. Int J Oncol. 2012. PMID: 22858681

4

Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model.

Alferez DG, Ryan AJ, Goodlad RA, Wright NA, Wilkinson RW. Alferez DG, et al. Int J Oncol. 2010 Oct;37(4):767-72. doi: 10.3892/ijo_00000726. Int J Oncol. 2010. PMID: 20811697

5

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.

Alferez D, Wilkinson RW, Watkins J, Poulsom R, Mandir N, Wedge SR, Pyrah IT, Smith NR, Jackson L, Ryan AJ, Goodlad RA. Alferez D, et al. Mol Cancer Ther. 2008 Mar;7(3):590-8. doi: 10.1158/1535-7163.MCT-07-0433. Mol Cancer Ther. 2008. PMID: 18347145

6

Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer.

Goodlad RA, Ryan AJ, Wedge SR, Pyrah IT, Alferez D, Poulsom R, Smith NR, Mandir N, Watkins AJ, Wilkinson RW. Goodlad RA, et al. Among authors: alferez d. Carcinogenesis. 2006 Oct;27(10):2133-9. doi: 10.1093/carcin/bgl113. Epub 2006 Jun 16. Carcinogenesis. 2006. PMID: 16782971

7

Detection of metabolic alterations in non-tumor gastrointestinal tissue of the Apc(Min/+) mouse by (1)H MAS NMR spectroscopy.

Backshall A, Alferez D, Teichert F, Wilson ID, Wilkinson RW, Goodlad RA, Keun HC. Backshall A, et al. Among authors: alferez d. J Proteome Res. 2009 Mar;8(3):1423-30. doi: 10.1021/pr800793w. J Proteome Res. 2009. PMID: 19159281

8

To best measure cell proliferation in samples from the intestine.

Alferez D, Goodlad RA. Alferez D, et al. Cell Prolif. 2007 Apr;40(2):231-40. doi: 10.1111/j.1365-2184.2007.00427.x. Cell Prolif. 2007. PMID: 17472729 Free PMC article. Review.

9

Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer.

Simões BM, Santiago-Gómez A, Chiodo C, Moreira T, Conole D, Lovell S, Alferez D, Eyre R, Spence K, Sarmiento-Castro A, Kohler B, Morisset L, Lanzino M, Andò S, Marangoni E, Sims AH, Tate EW, Howell SJ, Clarke RB. Simões BM, et al. Among authors: alferez d. Oncogene. 2020 Jun;39(25):4896-4908. doi: 10.1038/s41388-020-1335-z. Epub 2020 May 30. Oncogene. 2020. PMID: 32472077 Free PMC article.

10

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts.

Lefley D, Howard F, Arshad F, Bradbury S, Brown H, Tulotta C, Eyre R, Alférez D, Wilkinson JM, Holen I, Clarke RB, Ottewell P. Lefley D, et al. Among authors: alferez d. Breast Cancer Res. 2019 Nov 29;21(1):130. doi: 10.1186/s13058-019-1220-2. Breast Cancer Res. 2019. PMID: 31783893 Free PMC article.

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