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Des-acyl ghrelin fragments and analogues promote survival of pancreatic β-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats.
Granata R, Settanni F, Julien M, Nano R, Togliatto G, Trombetta A, Gallo D, Piemonti L, Brizzi MF, Abribat T, van Der Lely AJ, Ghigo E. Granata R, et al. Among authors: nano r. J Med Chem. 2012 Mar 22;55(6):2585-96. doi: 10.1021/jm201223m. Epub 2012 Mar 5. J Med Chem. 2012. PMID: 22352743 Free article.
Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.
Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G. Granata R, et al. Among authors: nano r. Endocrinology. 2007 Feb;148(2):512-29. doi: 10.1210/en.2006-0266. Epub 2006 Oct 26. Endocrinology. 2007. PMID: 17068144
Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.
Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E, Ghè C, Volante M, Papotti M, Muccioli G, Ghigo E. Granata R, et al. Among authors: nano r. Diabetes. 2008 Apr;57(4):967-79. doi: 10.2337/db07-1104. Epub 2007 Dec 27. Diabetes. 2008. PMID: 18162507
Beta-cell transplantation for diabetes therapy.
Sordi V, Nano R, Melzi R, Antonioli B, Piemonti L. Sordi V, et al. Among authors: nano r. Lancet. 2008 Jul 5;372(9632):28; author reply 29-30. doi: 10.1016/S0140-6736(08)60985-X. Lancet. 2008. PMID: 18603153 No abstract available.
217 results