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Des-acyl ghrelin fragments and analogues promote survival of pancreatic β-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats.
Granata R, Settanni F, Julien M, Nano R, Togliatto G, Trombetta A, Gallo D, Piemonti L, Brizzi MF, Abribat T, van Der Lely AJ, Ghigo E. Granata R, et al. Among authors: settanni f. J Med Chem. 2012 Mar 22;55(6):2585-96. doi: 10.1021/jm201223m. Epub 2012 Mar 5. J Med Chem. 2012. PMID: 22352743 Free article.
Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.
Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G. Granata R, et al. Among authors: settanni f. Endocrinology. 2007 Feb;148(2):512-29. doi: 10.1210/en.2006-0266. Epub 2006 Oct 26. Endocrinology. 2007. PMID: 17068144
Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.
Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E, Ghè C, Volante M, Papotti M, Muccioli G, Ghigo E. Granata R, et al. Among authors: settanni f. Diabetes. 2008 Apr;57(4):967-79. doi: 10.2337/db07-1104. Epub 2007 Dec 27. Diabetes. 2008. PMID: 18162507
Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart.
Granata R, Trovato L, Gallo MP, Destefanis S, Settanni F, Scarlatti F, Brero A, Ramella R, Volante M, Isgaard J, Levi R, Papotti M, Alloatti G, Ghigo E. Granata R, et al. Among authors: settanni f. Cardiovasc Res. 2009 Jul 15;83(2):303-12. doi: 10.1093/cvr/cvp090. Epub 2009 Mar 17. Cardiovasc Res. 2009. PMID: 19293247 Free article.
62 results