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Des-acyl ghrelin fragments and analogues promote survival of pancreatic β-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats.
Granata R, Settanni F, Julien M, Nano R, Togliatto G, Trombetta A, Gallo D, Piemonti L, Brizzi MF, Abribat T, van Der Lely AJ, Ghigo E. Granata R, et al. Among authors: van der lely aj. J Med Chem. 2012 Mar 22;55(6):2585-96. doi: 10.1021/jm201223m. Epub 2012 Mar 5. J Med Chem. 2012. PMID: 22352743 Free article.
Ghrelin drives GH secretion during fasting in man.
Muller AF, Lamberts SW, Janssen JA, Hofland LJ, Koetsveld PV, Bidlingmaier M, Strasburger CJ, Ghigo E, Van der Lely AJ. Muller AF, et al. Among authors: van der lely aj. Eur J Endocrinol. 2002 Feb;146(2):203-7. doi: 10.1530/eje.0.1460203. Eur J Endocrinol. 2002. PMID: 11834429 Free article. Clinical Trial.
Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans.
Broglio F, Koetsveld Pv Pv, Benso A, Gottero C, Prodam F, Papotti M, Muccioli G, Gauna C, Hofland L, Deghenghi R, Arvat E, Van Der Lely AJ, Ghigo E. Broglio F, et al. Among authors: van der lely aj. J Clin Endocrinol Metab. 2002 Oct;87(10):4829-32. doi: 10.1210/jc.2002-020956. J Clin Endocrinol Metab. 2002. PMID: 12364482 Clinical Trial.
325 results