Timperley CM - Search Results

1

Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ).

Niessen KV, Tattersall JE, Timperley CM, Bird M, Green C, Thiermann H, Worek F. Niessen KV, et al. Among authors: timperley cm. Drug Test Anal. 2012 Mar-Apr;4(3-4):292-7. doi: 10.1002/dta.410. Epub 2012 Feb 24. Drug Test Anal. 2012. PMID: 22362630

2

Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.

Blum MM, Timperley CM, Williams GR, Thiermann H, Worek F. Blum MM, et al. Among authors: timperley cm. Biochemistry. 2008 May 6;47(18):5216-24. doi: 10.1021/bi702222x. Epub 2008 Apr 9. Biochemistry. 2008. PMID: 18396898

3

Protection against nerve agent poisoning by a noncompetitive nicotinic antagonist.

Turner SR, Chad JE, Price M, Timperley CM, Bird M, Green AC, Tattersall JE. Turner SR, et al. Among authors: timperley cm. Toxicol Lett. 2011 Sep 25;206(1):105-11. doi: 10.1016/j.toxlet.2011.05.1035. Epub 2011 May 27. Toxicol Lett. 2011. PMID: 21641979

4

Interaction of bispyridinium compounds with the orthosteric binding site of human α7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs).

Niessen KV, Tattersall JE, Timperley CM, Bird M, Green C, Seeger T, Thiermann H, Worek F. Niessen KV, et al. Among authors: timperley cm. Toxicol Lett. 2011 Sep 25;206(1):100-4. doi: 10.1016/j.toxlet.2011.06.009. Epub 2011 Jun 16. Toxicol Lett. 2011. PMID: 21703337

5

Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro.

Seeger T, Eichhorn M, Lindner M, Niessen KV, Tattersall JE, Timperley CM, Bird M, Green AC, Thiermann H, Worek F. Seeger T, et al. Among authors: timperley cm. Toxicology. 2012 Apr 11;294(2-3):80-4. doi: 10.1016/j.tox.2012.02.002. Epub 2012 Feb 13. Toxicology. 2012. PMID: 22349640

6

Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length.

Niessen KV, Seeger T, Tattersall JE, Timperley CM, Bird M, Green C, Thiermann H, Worek F. Niessen KV, et al. Among authors: timperley cm. Chem Biol Interact. 2013 Dec 5;206(3):545-54. doi: 10.1016/j.cbi.2013.10.012. Epub 2013 Oct 21. Chem Biol Interact. 2013. PMID: 24157926

7

Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines.

Ring A, Strom BO, Turner SR, Timperley CM, Bird M, Green AC, Chad JE, Worek F, Tattersall JE. Ring A, et al. Among authors: timperley cm. PLoS One. 2015 Aug 14;10(8):e0135811. doi: 10.1371/journal.pone.0135811. eCollection 2015. PLoS One. 2015. PMID: 26274808 Free PMC article.

8

Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig.

Price ME, Docx CJ, Rice H, Fairhall SJ, Poole SJC, Bird M, Whiley L, Flint DP, Green AC, Timperley CM, Tattersall JEH. Price ME, et al. Among authors: timperley cm. Toxicol Lett. 2016 Feb 26;244:154-160. doi: 10.1016/j.toxlet.2015.08.013. Epub 2015 Sep 19. Toxicol Lett. 2016. PMID: 26325216

9

Evaluation of the benefit of the bispyridinium compound MB327 for the antidotal treatment of nerve agent-poisoned mice.

Kassa J, Pohanka M, Timperley CM, Bird M, Green AC, Tattersall JE. Kassa J, et al. Among authors: timperley cm. Toxicol Mech Methods. 2016 Jun;26(5):334-9. doi: 10.3109/15376516.2016.1162249. Epub 2016 Apr 20. Toxicol Mech Methods. 2016. PMID: 27097774

10

Evaluation of the Influence of Three Newly Developed Bispyridinium Anti-nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice.

Kassa J, Timperley CM, Bird M, Williams RL, Green AC, Tattersall JEH. Kassa J, et al. Among authors: timperley cm. Basic Clin Pharmacol Toxicol. 2018 Apr;122(4):429-435. doi: 10.1111/bcpt.12935. Epub 2017 Dec 5. Basic Clin Pharmacol Toxicol. 2018. PMID: 29117635 Free article.

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