Leder L - Search Results

1

Structural determinants of MALT1 protease activity.

Wiesmann C, Leder L, Blank J, Bernardi A, Melkko S, Decock A, D'Arcy A, Villard F, Erbel P, Hughes N, Freuler F, Nikolay R, Alves J, Bornancin F, Renatus M. Wiesmann C, et al. Among authors: leder l. J Mol Biol. 2012 May 25;419(1-2):4-21. doi: 10.1016/j.jmb.2012.02.018. Epub 2012 Feb 23. J Mol Biol. 2012. PMID: 22366302 Free article.

2

Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2.

Tirat A, Schilb A, Riou V, Leder L, Gerhartz B, Zimmermann J, Worpenberg S, Eidhoff U, Freuler F, Stettler T, Mayr L, Ottl J, Leuenberger B, Filipuzzi I. Tirat A, et al. Among authors: leder l. Anal Biochem. 2005 Aug 15;343(2):244-55. doi: 10.1016/j.ab.2005.04.023. Anal Biochem. 2005. PMID: 15963938

3

Evaluation of two novel tag-based labelling technologies for site-specific modification of proteins.

Tirat A, Freuler F, Stettler T, Mayr LM, Leder L. Tirat A, et al. Among authors: leder l. Int J Biol Macromol. 2006 Aug 15;39(1-3):66-76. doi: 10.1016/j.ijbiomac.2006.01.012. Epub 2006 Feb 28. Int J Biol Macromol. 2006. PMID: 16503347

4

Readout technologies for highly miniaturized kinase assays applicable to high-throughput screening in a 1536-well format.

Klumpp M, Boettcher A, Becker D, Meder G, Blank J, Leder L, Forstner M, Ottl J, Mayr LM. Klumpp M, et al. Among authors: leder l. J Biomol Screen. 2006 Sep;11(6):617-33. doi: 10.1177/1087057106288444. Epub 2006 Jun 7. J Biomol Screen. 2006. PMID: 16760365

5

New methods for efficient protein production in drug discovery.

Leder L, Freuler F, Forstner M, Mayr LM. Leder L, et al. Curr Opin Drug Discov Devel. 2007 Mar;10(2):193-202. Curr Opin Drug Discov Devel. 2007. PMID: 17436555 Review.

6

Development of a novel Gateway-based vector system for efficient, multiparallel protein expression in Escherichia coli.

Freuler F, Stettler T, Meyerhofer M, Leder L, Mayr LM. Freuler F, et al. Among authors: leder l. Protein Expr Purif. 2008 Jun;59(2):232-41. doi: 10.1016/j.pep.2008.02.003. Epub 2008 Feb 21. Protein Expr Purif. 2008. PMID: 18375142

7

The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations.

Leder L, Stark W, Freuler F, Marsh M, Meyerhofer M, Stettler T, Mayr LM, Britanova OV, Strukova LA, Chudakov DM, Souslova EA. Leder L, et al. Sensors (Basel). 2010;10(9):8143-60. doi: 10.3390/s100908143. Epub 2010 Aug 30. Sensors (Basel). 2010. PMID: 22163646 Free PMC article.

8

HDL-like discs for assaying membrane proteins in drug discovery.

Fiez-Vandal C, Leder L, Freuler F, Sykes D, Charlton SJ, Siehler S, Schopfer U, Duckely M. Fiez-Vandal C, et al. Among authors: leder l. Biophys Chem. 2012 May;165-166:56-61. doi: 10.1016/j.bpc.2012.03.005. Epub 2012 Mar 19. Biophys Chem. 2012. PMID: 22542136

9

Site-specific protein labeling in the pharmaceutical industry: experiences from novartis drug discovery.

Leder L. Leder L. Methods Mol Biol. 2015;1266:7-27. doi: 10.1007/978-1-4939-2272-7_2. Methods Mol Biol. 2015. PMID: 25560065 Review.

10

X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome.

Kallen J, Bergsdorf C, Arnaud B, Bernhard M, Brichet M, Cobos-Correa A, Elhajouji A, Freuler F, Galimberti I, Guibourdenche C, Haenni S, Holzinger S, Hunziker J, Izaac A, Kaufmann M, Leder L, Martus HJ, von Matt P, Polyakov V, Roethlisberger P, Roma G, Stiefl N, Uteng M, Lerchner A. Kallen J, et al. Among authors: leder l. ChemMedChem. 2018 Sep 19;13(18):1997-2007. doi: 10.1002/cmdc.201800344. Epub 2018 Aug 16. ChemMedChem. 2018. PMID: 29985556

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