Cohen TJ - Search Results

1

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies.

Irwin DJ, Cohen TJ, Grossman M, Arnold SE, Xie SX, Lee VM, Trojanowski JQ. Irwin DJ, et al. Among authors: cohen tj. Brain. 2012 Mar;135(Pt 3):807-18. doi: 10.1093/brain/aws013. Brain. 2012. PMID: 22366796 Free PMC article.

2

The acetylation of tau inhibits its function and promotes pathological tau aggregation.

Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ, Lee VM. Cohen TJ, et al. Nat Commun. 2011;2:252. doi: 10.1038/ncomms1255. Nat Commun. 2011. PMID: 21427723 Free PMC article.

3

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies.

Cohen TJ, Lee VM, Trojanowski JQ. Cohen TJ, et al. Trends Mol Med. 2011 Nov;17(11):659-67. doi: 10.1016/j.molmed.2011.06.004. Epub 2011 Jul 23. Trends Mol Med. 2011. PMID: 21783422 Free PMC article. Review.

4

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.

Cohen TJ, Hwang AW, Unger T, Trojanowski JQ, Lee VM. Cohen TJ, et al. EMBO J. 2012 Mar 7;31(5):1241-52. doi: 10.1038/emboj.2011.471. Epub 2011 Dec 23. EMBO J. 2012. PMID: 22193716 Free PMC article.

5

The microtubule-associated tau protein has intrinsic acetyltransferase activity.

Cohen TJ, Friedmann D, Hwang AW, Marmorstein R, Lee VM. Cohen TJ, et al. Nat Struct Mol Biol. 2013 Jun;20(6):756-62. doi: 10.1038/nsmb.2555. Epub 2013 Apr 28. Nat Struct Mol Biol. 2013. PMID: 23624859 Free PMC article.

6

Acetylated tau neuropathology in sporadic and hereditary tauopathies.

Irwin DJ, Cohen TJ, Grossman M, Arnold SE, McCarty-Wood E, Van Deerlin VM, Lee VM, Trojanowski JQ. Irwin DJ, et al. Among authors: cohen tj. Am J Pathol. 2013 Aug;183(2):344-51. doi: 10.1016/j.ajpath.2013.04.025. Am J Pathol. 2013. PMID: 23885714 Free PMC article.

7

An acetylation switch controls TDP-43 function and aggregation propensity.

Cohen TJ, Hwang AW, Restrepo CR, Yuan CX, Trojanowski JQ, Lee VM. Cohen TJ, et al. Nat Commun. 2015 Jan 5;6:5845. doi: 10.1038/ncomms6845. Nat Commun. 2015. PMID: 25556531 Free PMC article.

8

Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation.

Cohen TJ, Constance BH, Hwang AW, James M, Yuan CX. Cohen TJ, et al. PLoS One. 2016 Jul 6;11(7):e0158470. doi: 10.1371/journal.pone.0158470. eCollection 2016. PLoS One. 2016. PMID: 27383765 Free PMC article.

9

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.

Hwang AW, Trzeciakiewicz H, Friedmann D, Yuan CX, Marmorstein R, Lee VM, Cohen TJ. Hwang AW, et al. Among authors: cohen tj. PLoS One. 2016 Dec 21;11(12):e0168913. doi: 10.1371/journal.pone.0168913. eCollection 2016. PLoS One. 2016. PMID: 28002468 Free PMC article.

10

The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging.

Wander CM, Tseng JH, Song S, Al Housseiny HA, Tart DS, Ajit A, Ian Shih YY, Lobrovich R, Song J, Meeker RB, Irwin DJ, Cohen TJ. Wander CM, et al. Among authors: cohen tj. iScience. 2020 Jul 24;23(7):101255. doi: 10.1016/j.isci.2020.101255. Epub 2020 Jun 10. iScience. 2020. PMID: 32585593 Free PMC article.

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