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An investigation into the utility of a multi-compartmental, dynamic, system of the upper gastrointestinal tract to support formulation development and establish bioequivalence of poorly soluble drugs.
AAPS J. 2012 Jun;14(2):196-205. doi: 10.1208/s12248-012-9333-x. Epub 2012 Feb 29.
AAPS J. 2012.
PMID: 22374384
Free PMC article.
Clinical Trial.
Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation.
Larsen AT, Ohlsson AG, Polentarutti B, Barker RA, Phillips AR, Abu-Rmaileh R, Dickinson PA, Abrahamsson B, Ostergaard J, Müllertz A.
Larsen AT, et al. Among authors: abu rmaileh r.
Eur J Pharm Sci. 2013 Jan 23;48(1-2):339-50. doi: 10.1016/j.ejps.2012.11.004. Epub 2012 Nov 21.
Eur J Pharm Sci. 2013.
PMID: 23178440
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Bioavailability of cinnarizine in dogs: effect of SNEDDS loading level and correlation with cinnarizine solubilization during in vitro lipolysis.
Larsen AT, Åkesson P, Juréus A, Saaby L, Abu-Rmaileh R, Abrahamsson B, Østergaard J, Müllertz A.
Larsen AT, et al. Among authors: abu rmaileh r.
Pharm Res. 2013 Dec;30(12):3101-13. doi: 10.1007/s11095-013-1145-x. Epub 2013 Aug 15.
Pharm Res. 2013.
PMID: 23949249
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SNEDDS Containing Poorly Water Soluble Cinnarizine; Development and in Vitro Characterization of Dispersion, Digestion and Solubilization.
Larsen AT, Ogbonna A, Abu-Rmaileh R, Abrahamsson B, Ostergaard J, Müllertz A.
Larsen AT, et al. Among authors: abu rmaileh r.
Pharmaceutics. 2012 Dec 14;4(4):641-65. doi: 10.3390/pharmaceutics4040641.
Pharmaceutics. 2012.
PMID: 24300374
Free PMC article.
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