Perera NM - Search Results

1

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity.

Tibarewal P, Zilidis G, Spinelli L, Schurch N, Maccario H, Gray A, Perera NM, Davidson L, Barton GJ, Leslie NR. Tibarewal P, et al. Among authors: perera nm. Sci Signal. 2012 Feb 28;5(213):ra18. doi: 10.1126/scisignal.2002138. Sci Signal. 2012. PMID: 22375056

2

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.

Davidson L, Maccario H, Perera NM, Yang X, Spinelli L, Tibarewal P, Glancy B, Gray A, Weijer CJ, Downes CP, Leslie NR. Davidson L, et al. Among authors: perera nm. Oncogene. 2010 Feb 4;29(5):687-97. doi: 10.1038/onc.2009.384. Epub 2009 Nov 16. Oncogene. 2010. PMID: 19915616 Free PMC article.

3

Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN.

Downes CP, Perera N, Ross S, Leslie NR. Downes CP, et al. Biochem Soc Symp. 2007;(74):69-80. doi: 10.1042/BSS0740069. Biochem Soc Symp. 2007. PMID: 17233581 Review.

4

Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.

Downes CP, Ross S, Maccario H, Perera N, Davidson L, Leslie NR. Downes CP, et al. Adv Enzyme Regul. 2007;47:184-94. doi: 10.1016/j.advenzreg.2006.12.018. Epub 2006 Dec 30. Adv Enzyme Regul. 2007. PMID: 17343901 Review. No abstract available.

5

PTEN is destabilized by phosphorylation on Thr366.

Maccario H, Perera NM, Davidson L, Downes CP, Leslie NR. Maccario H, et al. Among authors: perera nm. Biochem J. 2007 Aug 1;405(3):439-44. doi: 10.1042/BJ20061837. Biochem J. 2007. PMID: 17444818 Free PMC article.

6

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

Maccario H, Perera NM, Gray A, Downes CP, Leslie NR. Maccario H, et al. Among authors: perera nm. J Biol Chem. 2010 Apr 23;285(17):12620-8. doi: 10.1074/jbc.M109.072280. Epub 2010 Feb 22. J Biol Chem. 2010. PMID: 20177066 Free PMC article.

7

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.

Walker SM, Leslie NR, Perera NM, Batty IH, Downes CP. Walker SM, et al. Among authors: perera nm. Biochem J. 2004 Apr 15;379(Pt 2):301-7. doi: 10.1042/BJ20031839. Biochem J. 2004. PMID: 14711368 Free PMC article.

8

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells.

Ning K, Miller LC, Laidlaw HA, Burgess LA, Perera NM, Downes CP, Leslie NR, Ashford ML. Ning K, et al. Among authors: perera nm. EMBO J. 2006 Jun 7;25(11):2377-87. doi: 10.1038/sj.emboj.7601118. Epub 2006 May 4. EMBO J. 2006. PMID: 16675953 Free PMC article.

9

Hypo-osmotic stress activates Plc1p-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol Hexakisphosphate accumulation in yeast.

Perera NM, Michell RH, Dove SK. Perera NM, et al. J Biol Chem. 2004 Feb 13;279(7):5216-26. doi: 10.1074/jbc.M305068200. Epub 2003 Nov 18. J Biol Chem. 2004. PMID: 14625296 Free article.

10

Morton Medal Lecture. New insights into the roles of phosphoinositides and inositol polyphosphates in yeast.

Michell RH, Perera NM, Dove SK. Michell RH, et al. Among authors: perera nm. Biochem Soc Trans. 2003 Feb;31(Pt 1):11-5. doi: 10.1042/bst0310011. Biochem Soc Trans. 2003. PMID: 12546644

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