Lavie A - Search Results

1

Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer.

Neschadim A, Wang JC, Lavie A, Medin JA. Neschadim A, et al. Among authors: lavie a. Cancer Gene Ther. 2012 May;19(5):320-7. doi: 10.1038/cgt.2012.4. Epub 2012 Mar 2. Cancer Gene Ther. 2012. PMID: 22388453

2

Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy.

Sato T, Neschadim A, Konrad M, Fowler DH, Lavie A, Medin JA. Sato T, et al. Among authors: lavie a. Mol Ther. 2007 May;15(5):962-70. doi: 10.1038/mt.sj.6300122. Epub 2007 Mar 20. Mol Ther. 2007. PMID: 17375075 Free article.

3

Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase.

Neschadim A, Wang JC, Sato T, Fowler DH, Lavie A, Medin JA. Neschadim A, et al. Among authors: lavie a. Mol Ther. 2012 May;20(5):1002-13. doi: 10.1038/mt.2011.298. Epub 2012 Jan 24. Mol Ther. 2012. PMID: 22273576 Free PMC article.

4

The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer.

Sato T, Neschadim A, Lavie A, Yanagisawa T, Medin JA. Sato T, et al. Among authors: lavie a. PLoS One. 2013 Oct 23;8(10):e78711. doi: 10.1371/journal.pone.0078711. eCollection 2013. PLoS One. 2013. PMID: 24194950 Free PMC article.

5

Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.

Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. Murphy JM, et al. Among authors: lavie a. J Med Chem. 2013 Sep 12;56(17):6696-708. doi: 10.1021/jm400457y. Epub 2013 Aug 15. J Med Chem. 2013. PMID: 23947754 Free PMC article.

6

Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.

Nomme J, Li Z, Gipson RM, Wang J, Armijo AL, Le T, Poddar S, Smith T, Santarsiero BD, Nguyen HA, Czernin J, Alexandrova AN, Jung ME, Radu CG, Lavie A. Nomme J, et al. Among authors: lavie a. J Med Chem. 2014 Nov 26;57(22):9480-94. doi: 10.1021/jm501124j. Epub 2014 Nov 7. J Med Chem. 2014. PMID: 25341194 Free PMC article.

7

Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues.

Hazra S, Ort S, Konrad M, Lavie A. Hazra S, et al. Among authors: lavie a. Biochemistry. 2010 Aug 10;49(31):6784-90. doi: 10.1021/bi100839e. Biochemistry. 2010. PMID: 20614893 Free PMC article.

8

Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase.

Hazra S, Sabini E, Ort S, Konrad M, Lavie A. Hazra S, et al. Among authors: lavie a. Biochemistry. 2009 Feb 17;48(6):1256-63. doi: 10.1021/bi802062w. Biochemistry. 2009. PMID: 19159229 Free PMC article.

9

Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.

Campbell DO, Yaghoubi SS, Su Y, Lee JT, Auerbach MS, Herschman H, Satyamurthy N, Czernin J, Lavie A, Radu CG. Campbell DO, et al. Among authors: lavie a. J Biol Chem. 2012 Jan 2;287(1):446-454. doi: 10.1074/jbc.M111.314666. Epub 2011 Nov 9. J Biol Chem. 2012. PMID: 22074768 Free PMC article. Clinical Trial.

10

Targeted Delivery of Deoxycytidine Kinase to Her2-Positive Cells Enhances the Efficacy of the Nucleoside Analog Fludarabine.

Koduvayur SP, Su Y, Kay BK, Lavie A. Koduvayur SP, et al. Among authors: lavie a. PLoS One. 2016 Jun 9;11(6):e0157114. doi: 10.1371/journal.pone.0157114. eCollection 2016. PLoS One. 2016. PMID: 27280468 Free PMC article.

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