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Population bulk segregant mapping uncovers resistance mutations and the mode of action of a chitin synthesis inhibitor in arthropods.
Van Leeuwen T, Demaeght P, Osborne EJ, Dermauw W, Gohlke S, Nauen R, Grbic M, Tirry L, Merzendorfer H, Clark RM. Van Leeuwen T, et al. Among authors: gohlke s. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4407-12. doi: 10.1073/pnas.1200068109. Epub 2012 Mar 5. Proc Natl Acad Sci U S A. 2012. PMID: 22393009 Free PMC article.
Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality.
Wang R, Gomez Salazar M, Pruñonosa Cervera I, Coutts A, French K, Pinto MM, Gohlke S, García-Martín R, Blüher M, Schofield CJ, Kourtzelis I, Stimson RH, Bénézech C, Christian M, Schulz TJ, Gudmundsson EF, Jennings LL, Gudnason VG, Chavakis T, Morton NM, Emilsson V, Michailidou Z. Wang R, et al. Among authors: gohlke s. Nat Commun. 2024 Aug 29;15(1):7483. doi: 10.1038/s41467-024-51718-7. Nat Commun. 2024. PMID: 39209825 Free PMC article.
Skeletal muscle p53-depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation.
Lenihan-Geels G, Garcia Carrizo F, Leer M, Gohlke S, Oster M, Pöhle-Kronawitter S, Ott C, Chadt A, Reinisch IN, Galhuber M, Li C, Jonas W, Jähnert M, Klaus S, Al-Hasani H, Grune T, Schürmann A, Madl T, Prokesch A, Schupp M, Schulz TJ. Lenihan-Geels G, et al. Among authors: gohlke s. J Cachexia Sarcopenia Muscle. 2024 Oct;15(5):1772-1784. doi: 10.1002/jcsm.13529. Epub 2024 Jul 15. J Cachexia Sarcopenia Muscle. 2024. PMID: 39010299 Free PMC article.
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.
Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Bartelt A, Jastroch M, Wachten D, Kornfeld JW. Khani S, et al. Among authors: gohlke s. Nat Metab. 2024 Jun;6(6):1053-1075. doi: 10.1038/s42255-024-01033-8. Epub 2024 Apr 29. Nat Metab. 2024. PMID: 38684889
Adipose retinol saturase is regulated by β-adrenergic signaling and its deletion impairs lipolysis in adipocytes and acute cold tolerance in mice.
Li C, Kiefer MF, Dittrich S, Flores RE, Meng Y, Yang N, Wulff S, Gohlke S, Sommerfeld M, Wowro SJ, Petricek KM, Dürbeck D, Spranger L, Mai K, Scholz H, Schulz TJ, Schupp M. Li C, et al. Among authors: gohlke s. Mol Metab. 2024 Jan;79:101855. doi: 10.1016/j.molmet.2023.101855. Epub 2023 Dec 19. Mol Metab. 2024. PMID: 38128827 Free PMC article.
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