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The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Hakki T, Hübel K, Waldmann H, Bernhardt R. Hakki T, et al. Among authors: hubel k. J Steroid Biochem Mol Biol. 2011 May;125(1-2):120-8. doi: 10.1016/j.jsbmb.2010.12.011. Epub 2010 Dec 28. J Steroid Biochem Mol Biol. 2011. PMID: 21193036
Natural product-inspired cascade synthesis yields modulators of centrosome integrity.
Dückert H, Pries V, Khedkar V, Menninger S, Bruss H, Bird AW, Maliga Z, Brockmeyer A, Janning P, Hyman A, Grimme S, Schürmann M, Preut H, Hübel K, Ziegler S, Kumar K, Waldmann H. Dückert H, et al. Among authors: hubel k. Nat Chem Biol. 2011 Dec 25;8(2):179-84. doi: 10.1038/nchembio.758. Nat Chem Biol. 2011. PMID: 22198731
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis.
Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, Khudayberdiev S, Leuschner PF, Busch CJ, Kane C, Hübel K, Dekker F, Hedberg C, Rengarajan B, Drepper C, Waldmann H, Kauppinen S, Greenberg ME, Draguhn A, Rehmsmeier M, Martinez J, Schratt GM. Siegel G, et al. Among authors: hubel k. Nat Cell Biol. 2009 Jun;11(6):705-16. doi: 10.1038/ncb1876. Epub 2009 May 24. Nat Cell Biol. 2009. PMID: 19465924 Free PMC article.
The Ras pathway modulator melophlin A targets dynamins.
Knoth T, Warburg K, Katzka C, Rai A, Wolf A, Brockmeyer A, Janning P, Reubold TF, Eschenburg S, Manstein DJ, Hübel K, Kaiser M, Waldmann H. Knoth T, et al. Among authors: hubel k. Angew Chem Int Ed Engl. 2009;48(39):7240-5. doi: 10.1002/anie.200902023. Angew Chem Int Ed Engl. 2009. PMID: 19722243 No abstract available.
Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Bureik M, Hübel K, Dragan CA, Scher J, Becker H, Lenz N, Bernhardt R. Bureik M, et al. Among authors: hubel k. Mol Cell Endocrinol. 2004 Mar 31;217(1-2):249-54. doi: 10.1016/j.mce.2003.10.027. Mol Cell Endocrinol. 2004. PMID: 15134825
186 results