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Akt is negatively regulated by the MULAN E3 ligase.
Bae S, Kim SY, Jung JH, Yoon Y, Cha HJ, Lee H, Kim K, Kim J, An IS, Kim J, Um HD, Park IC, Lee SJ, Nam SY, Jin YW, Lee JH, An S. Bae S, et al. Among authors: an is, an s. Cell Res. 2012 May;22(5):873-85. doi: 10.1038/cr.2012.38. Epub 2012 Mar 13. Cell Res. 2012. PMID: 22410793 Free PMC article.
TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation.
Bae S, Jung JH, Kim K, An IS, Kim SY, Lee JH, Park IC, Jin YW, Lee SJ, An S. Bae S, et al. Among authors: an is, an s. FEBS Lett. 2012 Sep 21;586(19):3057-63. doi: 10.1016/j.febslet.2012.07.022. Epub 2012 Jul 20. FEBS Lett. 2012. PMID: 22819825 Free article.
Murine double minute (MDM2) is an E3 ligase that promotes ubiquitination and degradation of tumor suppressor protein 53 (p53). ...
Murine double minute (MDM2) is an E3 ligase that promotes ubiquitination and degradation of tumor suppressor protein 53 (p53). …
TRIAD1 is negatively regulated by the MDM2 E3 ligase.
Bae S, Jung JH, An IS, Kim OY, Lee MJ, Lee JH, Park IC, Lee SJ, An S. Bae S, et al. Among authors: an is, an s. Oncol Rep. 2012 Nov;28(5):1924-8. doi: 10.3892/or.2012.2005. Epub 2012 Aug 31. Oncol Rep. 2012. PMID: 22940738
E3 ligase RCHY1 negatively regulates HDAC2.
Choi M, Choi YM, An IS, Bae S, Jung JH, An S. Choi M, et al. Among authors: an is. Biochem Biophys Res Commun. 2020 Jan 1;521(1):37-41. doi: 10.1016/j.bbrc.2019.10.049. Epub 2019 Oct 17. Biochem Biophys Res Commun. 2020. PMID: 31630802
The hypoxia-mimetic agent cobalt chloride induces cell cycle arrest and alters gene expression in U266 multiple myeloma cells.
Bae S, Jeong HJ, Cha HJ, Kim K, Choi YM, An IS, Koh HJ, Lim DJ, Lee SJ, An S. Bae S, et al. Among authors: an is, an s. Int J Mol Med. 2012 Nov;30(5):1180-6. doi: 10.3892/ijmm.2012.1115. Epub 2012 Aug 31. Int J Mol Med. 2012. PMID: 22941251
Hypoxia is a common feature of tumors that occurs across a wide variety of malignancies. Multiple myeloma is an incurable malignant disorder of plasma cells in the bone marrow. Although bone marrow hypoxia is crucial for normal hematopoiesis, the effec …
Hypoxia is a common feature of tumors that occurs across a wide variety of malignancies. Multiple myeloma is an incurab …
Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells.
Kim K, An S, Cha HJ, Choi YM, Choi SJ, An IS, Lee HG, Min YH, Lee SJ, Bae S. Kim K, et al. Among authors: an is, an s. Oncol Lett. 2013 Feb;5(2):588-592. doi: 10.3892/ol.2012.1054. Epub 2012 Nov 30. Oncol Lett. 2013. PMID: 23420263 Free PMC article.
Non-small cell lung cancer (NSCLC) is the most deadly type of cancer worldwide. Although a number of therapies are used in NSCLC treatment, their therapeutic efficacy remains low. ...BID and FOS, which are known apoptosis activators, were upregulated by lenalidomide treatm …
Non-small cell lung cancer (NSCLC) is the most deadly type of cancer worldwide. Although a number of therapies are used in NSCLC trea …
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