Li YM - Search Results

1

Development of clickable active site-directed photoaffinity probes for γ-secretase.

Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS. Crump CJ, et al. Among authors: li ym. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2997-3000. doi: 10.1016/j.bmcl.2012.02.027. Epub 2012 Feb 20. Bioorg Med Chem Lett. 2012. PMID: 22418280 Free PMC article.

2

Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors.

Chun J, Yin YI, Yang G, Tarassishin L, Li YM. Chun J, et al. Among authors: li ym. J Org Chem. 2004 Oct 15;69(21):7344-7. doi: 10.1021/jo0486948. J Org Chem. 2004. PMID: 15471490

3

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct.

Tarassishin L, Yin YI, Bassit B, Li YM. Tarassishin L, et al. Among authors: li ym. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17050-5. doi: 10.1073/pnas.0408007101. Epub 2004 Nov 24. Proc Natl Acad Sci U S A. 2004. PMID: 15563588 Free PMC article.

4

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.

Coburn CA, Stachel SJ, Li YM, Rush DM, Steele TG, Chen-Dodson E, Holloway MK, Xu M, Huang Q, Lai MT, DiMuzio J, Crouthamel MC, Shi XP, Sardana V, Chen Z, Munshi S, Kuo L, Makara GM, Annis DA, Tadikonda PK, Nash HM, Vacca JP, Wang T. Coburn CA, et al. Among authors: li ym. J Med Chem. 2004 Dec 2;47(25):6117-9. doi: 10.1021/jm049388p. J Med Chem. 2004. PMID: 15566281

5

{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.

Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM. Yin YI, et al. Among authors: li ym. J Biol Chem. 2007 Aug 10;282(32):23639-44. doi: 10.1074/jbc.M704601200. Epub 2007 Jun 7. J Biol Chem. 2007. PMID: 17556361 Free article.

6

Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.

Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Placanica L, et al. Among authors: li ym. J Biol Chem. 2009 Jan 30;284(5):2967-2977. doi: 10.1074/jbc.M807269200. Epub 2008 Nov 25. J Biol Chem. 2009. PMID: 19036728 Free PMC article.

7

Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors.

Yang G, Yin YI, Chun J, Shelton CC, Ouerfelli O, Li YM. Yang G, et al. Among authors: li ym. Bioorg Med Chem Lett. 2009 Feb 1;19(3):922-5. doi: 10.1016/j.bmcl.2008.11.117. Epub 2008 Dec 7. Bioorg Med Chem Lett. 2009. PMID: 19097779 Free PMC article.

8

Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease.

Placanica L, Zhu L, Li YM. Placanica L, et al. Among authors: li ym. PLoS One. 2009;4(4):e5088. doi: 10.1371/journal.pone.0005088. Epub 2009 Apr 7. PLoS One. 2009. PMID: 19352431 Free PMC article.

9

A miniaturized 1536-well format gamma-secretase assay.

Shelton CC, Tian Y, Shum D, Radu C, Djaballah H, Li YM. Shelton CC, et al. Among authors: li ym. Assay Drug Dev Technol. 2009 Oct;7(5):461-70. doi: 10.1089/adt.2009.0202. Assay Drug Dev Technol. 2009. PMID: 19715456 Free PMC article.

10

Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.

Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM. Shelton CC, et al. Among authors: li ym. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20228-33. doi: 10.1073/pnas.0910757106. Epub 2009 Nov 11. Proc Natl Acad Sci U S A. 2009. PMID: 19906985 Free PMC article.

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