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Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation.
Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Mannebach S, Wissenbach U, Vennekens R, Middendorff R, Flockerzi V, Freichel M. Weissgerber P, et al. J Biol Chem. 2012 May 25;287(22):17930-41. doi: 10.1074/jbc.M111.328286. Epub 2012 Mar 15. J Biol Chem. 2012. PMID: 22427671 Free PMC article.
Replacement of aspartate residue 541 by alanine (D541A) in the pore of TRPV6 channels in mice disrupts Ca(2+) absorption by the epididymal epithelium, resulting in abnormally high Ca(2+) concentrations in epididymal luminal fluid and in a dramatic but incomplete loss of sperm mot …
Replacement of aspartate residue 541 by alanine (D541A) in the pore of TRPV6 channels in mice disrupts Ca(2+) absorption by the epididymal e …
Mutations of calcium channel beta subunit genes in mice.
Freise D, Himmerkus N, Schroth G, Trost C, Weissgerber P, Freichel M, Flockerzi V. Freise D, et al. Among authors: weissgerber p. Biol Chem. 1999 Jul-Aug;380(7-8):897-902. doi: 10.1515/BC.1999.110. Biol Chem. 1999. PMID: 10494839 Review.
Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models.
Freichel M, Vennekens R, Olausson J, Hoffmann M, Müller C, Stolz S, Scheunemann J, Weissgerber P, Flockerzi V. Freichel M, et al. Among authors: weissgerber p. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1352-8. doi: 10.1016/j.bbrc.2004.08.041. Biochem Biophys Res Commun. 2004. PMID: 15336983 Review.
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