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691 results

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Page 1
2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1.
Blanchard S, Soh CK, Lee CP, Poulsen A, Bonday Z, Goh KL, Goh KC, Goh MK, Pasha MK, Wang H, Williams M, Wood JM, Ethirajulu K, Dymock BW. Blanchard S, et al. Among authors: lee cp. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2880-4. doi: 10.1016/j.bmcl.2012.02.058. Epub 2012 Feb 27. Bioorg Med Chem Lett. 2012. PMID: 22437109
Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer.
William AD, Lee AC, Goh KC, Blanchard S, Poulsen A, Teo EL, Nagaraj H, Lee CP, Wang H, Williams M, Sun ET, Hu C, Jayaraman R, Pasha MK, Ethirajulu K, Wood JM, Dymock BW. William AD, et al. Among authors: lee cp, lee ac. J Med Chem. 2012 Jan 12;55(1):169-96. doi: 10.1021/jm201112g. Epub 2011 Dec 29. J Med Chem. 2012. PMID: 22148278
Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthritis.
William AD, Lee AC, Poulsen A, Goh KC, Madan B, Hart S, Tan E, Wang H, Nagaraj H, Chen D, Lee CP, Sun ET, Jayaraman R, Pasha MK, Ethirajulu K, Wood JM, Dymock BW. William AD, et al. Among authors: lee cp, lee ac. J Med Chem. 2012 Mar 22;55(6):2623-40. doi: 10.1021/jm201454n. Epub 2012 Mar 6. J Med Chem. 2012. PMID: 22339472
Structure-based design of PDK1 inhibitors.
Poulsen A, Blanchard S, Soh CK, Lee C, Williams M, Wang H, Dymock B. Poulsen A, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):305-7. doi: 10.1016/j.bmcl.2011.11.006. Epub 2011 Nov 9. Bioorg Med Chem Lett. 2012. PMID: 22119465
Cardiopulmonary Substructure Doses are Not Correlated With Cardiorespiratory Fitness Among Breast Cancer Survivors Treated With Contemporary Radiation Therapy.
Thor M, Scott JM, Reiner AS, Hong L, Yu AF, Apte A, McCormick B, Perez-Andujar A, Lee CP, Cervino L, Harrison J, Liang X, Patel P, Dauer LT, Moskowitz CS, Bernstein JL. Thor M, et al. Among authors: lee cp. Adv Radiat Oncol. 2024 Sep 30;9(12):101613. doi: 10.1016/j.adro.2024.101613. eCollection 2024 Dec. Adv Radiat Oncol. 2024. PMID: 39777365 Free PMC article.
A digital, decentralized trial of exercise therapy in patients with cancer.
Underwood WP, Michalski MG, Lee CP, Fickera GA, Chun SS, Eng SE, Liu LY, Tsai BL, Moskowitz CS, Lavery JA, Van Zee KJ, Gardner GJ, Mueller JJ, Dang CT, Ehdaie B, Laudone VP, Eastham JA, Scott JM, Boutros PC, Jones LW. Underwood WP, et al. Among authors: lee cp. NPJ Digit Med. 2024 Oct 28;7(1):304. doi: 10.1038/s41746-024-01288-1. NPJ Digit Med. 2024. PMID: 39468290 Free PMC article.
691 results