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The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A. Hundhausen C, et al. Among authors: saftig p. Blood. 2003 Aug 15;102(4):1186-95. doi: 10.1182/blood-2002-12-3775. Epub 2003 Apr 24. Blood. 2003. PMID: 12714508 Free article.
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A. Abel S, et al. Among authors: saftig p. J Immunol. 2004 May 15;172(10):6362-72. doi: 10.4049/jimmunol.172.10.6362. J Immunol. 2004. PMID: 15128827
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.
Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B. Dominguez D, et al. Among authors: saftig p. J Biol Chem. 2005 Sep 2;280(35):30797-806. doi: 10.1074/jbc.M505249200. Epub 2005 Jun 29. J Biol Chem. 2005. PMID: 15987683 Free article.
Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum.
Budagian V, Bulanova E, Orinska Z, Duitman E, Brandt K, Ludwig A, Hartmann D, Lemke G, Saftig P, Bulfone-Paus S. Budagian V, et al. Among authors: saftig p. Mol Cell Biol. 2005 Nov;25(21):9324-39. doi: 10.1128/MCB.25.21.9324-9339.2005. Mol Cell Biol. 2005. Retraction in: Mol Cell Biol. 2011 Mar;31(6):1330. doi: 10.1128/MCB.05019-11 PMID: 16227584 Free PMC article. Retracted.
346 results