Roques BP - Search Results

1

Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain.

Roques BP, Fournié-Zaluski MC, Wurm M. Roques BP, et al. Nat Rev Drug Discov. 2012 Apr;11(4):292-310. doi: 10.1038/nrd3673. Nat Rev Drug Discov. 2012. PMID: 22460123 Review.

2

New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment.

Poras H, Bonnard E, Dangé E, Fournié-Zaluski MC, Roques BP. Poras H, et al. Among authors: roques bp. J Med Chem. 2014 Jul 10;57(13):5748-63. doi: 10.1021/jm500602h. Epub 2014 Jun 24. J Med Chem. 2014. PMID: 24927250

3

Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route.

Poras H, Bonnard E, Fournié-Zaluski MC, Roques BP. Poras H, et al. Among authors: roques bp. Eur J Med Chem. 2015 Sep 18;102:58-67. doi: 10.1016/j.ejmech.2015.07.027. Epub 2015 Jul 17. Eur J Med Chem. 2015. PMID: 26241877

4

A sensitive fluorigenic substrate for selective in vitro and in vivo assay of leukotriene A4 hydrolase activity.

Poras H, Duquesnoy S, Fournié-Zaluski MC, Ratinaud-Giraud C, Roques BP, Ouimet T. Poras H, et al. Among authors: roques bp. Anal Biochem. 2013 Oct 15;441(2):152-61. doi: 10.1016/j.ab.2013.06.016. Epub 2013 Jul 11. Anal Biochem. 2013. PMID: 23851339

5

Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain.

Bonnard E, Poras H, Nadal X, Maldonado R, Fournié-Zaluski MC, Roques BP. Bonnard E, et al. Among authors: roques bp. Pharmacol Res Perspect. 2015 Mar;3(2):e00116. doi: 10.1002/prp2.116. Epub 2015 Jan 30. Pharmacol Res Perspect. 2015. PMID: 25692029 Free PMC article.

6

Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain.

Bonnard E, Poras H, Fournié-Zaluski MC, Roques BP. Bonnard E, et al. Among authors: roques bp. Eur J Pharmacol. 2016 Oct 5;788:176-182. doi: 10.1016/j.ejphar.2016.05.041. Epub 2016 Jun 4. Eur J Pharmacol. 2016. PMID: 27266667

7

Substituted α-mercaptoketones, new types of specific neprilysin inhibitors.

Poras H, Patouret R, Leiris S, Ouimet T, Fournié-Zaluski MC, Roques BP. Poras H, et al. Among authors: roques bp. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3883-3890. doi: 10.1016/j.bmcl.2017.06.050. Epub 2017 Jun 21. Bioorg Med Chem Lett. 2017. PMID: 28676269

8

Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain.

González-Rodríguez S, Poras H, Menéndez L, Lastra A, Ouimet T, Fournié-Zaluski MC, Roques BP, Baamonde A. González-Rodríguez S, et al. Among authors: roques bp. Scand J Pain. 2017 Jan;14:25-38. doi: 10.1016/j.sjpain.2016.09.011. Epub 2016 Nov 1. Scand J Pain. 2017. PMID: 28850427 Free article.

9

Antinociceptive effect of systemic PC 12, a prodrug mixed inhibitor of enkephalin-degrading enzymes, in normal and arthritic rats.

Perrot S, Kayser V, Fournié-Zaluski MC, Roques BP, Guilbaud G. Perrot S, et al. Among authors: roques bp. Eur J Pharmacol. 1993 Sep 7;241(1):129-33. doi: 10.1016/0014-2999(93)90944-d. Eur J Pharmacol. 1993. PMID: 7901035

10

Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics.

Chen H, Noble F, Coric P, Fournie-Zaluski MC, Roques BP. Chen H, et al. Among authors: roques bp. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12028-33. doi: 10.1073/pnas.95.20.12028. Proc Natl Acad Sci U S A. 1998. PMID: 9751784 Free PMC article.

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