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Page 1
Targeting the MDM2/MDM4 interaction interface as a promising approach for p53 reactivation therapy.
Pellegrino M, Mancini F, Lucà R, Coletti A, Giacchè N, Manni I, Arisi I, Florenzano F, Teveroni E, Buttarelli M, Fici L, Brandi R, Bruno T, Fanciulli M, D'Onofrio M, Piaggio G, Pellicciari R, Pontecorvi A, Marine JC, Macchiarulo A, Moretti F. Pellegrino M, et al. Cancer Res. 2015 Nov 1;75(21):4560-72. doi: 10.1158/0008-5472.CAN-15-0439. Epub 2015 Sep 10. Cancer Res. 2015. PMID: 26359458
MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.
Mancini F, Teveroni E, Di Conza G, Monteleone V, Arisi I, Pellegrino M, Buttarelli M, Pieroni L, D'Onofrio M, Urbani A, Pontecorvi A, Mazzone M, Moretti F. Mancini F, et al. Among authors: pellegrino m. Mol Cancer. 2017 Mar 7;16(1):55. doi: 10.1186/s12943-017-0626-7. Mol Cancer. 2017. PMID: 28270148 Free PMC article.
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.
Mancini F, Di Conza G, Pellegrino M, Rinaldo C, Prodosmo A, Giglio S, D'Agnano I, Florenzano F, Felicioni L, Buttitta F, Marchetti A, Sacchi A, Pontecorvi A, Soddu S, Moretti F. Mancini F, et al. Among authors: pellegrino m. EMBO J. 2009 Jul 8;28(13):1926-39. doi: 10.1038/emboj.2009.154. Epub 2009 Jun 11. EMBO J. 2009. PMID: 19521340 Free PMC article.
Estrogens Counteract Platinum-Chemosensitivity by Modifying the Subcellular Localization of MDM4.
Lucà R, di Blasio G, Gallo D, Monteleone V, Manni I, Fici L, Buttarelli M, Ciolli G, Pellegrino M, Teveroni E, Maiullari S, Ciucci A, Apollo A, Mancini F, Gentileschi MP, Zannoni GF, Pontecorvi A, Scambia G, Moretti F. Lucà R, et al. Among authors: pellegrino m. Cancers (Basel). 2019 Sep 12;11(9):1349. doi: 10.3390/cancers11091349. Cancers (Basel). 2019. PMID: 31547268 Free PMC article.
Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53.
Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, Sorino C, Gentileschi MP, Germoni S, Monteleone V, Pellegrino M, Kann M, De Meo PD, Pallocca M, Höpker K, Moretti F, Mattei E, Reinhardt HC, Floridi A, Passananti C, Benzing T, Blandino G, Fanciulli M. Desantis A, et al. Among authors: pellegrino m. Cell Death Dis. 2015 May 21;6(5):e1764. doi: 10.1038/cddis.2015.117. Cell Death Dis. 2015. PMID: 25996291 Free PMC article.
Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents.
Canu N, Pagano I, La Rosa LR, Pellegrino M, Ciotti MT, Mercanti D, Moretti F, Sposato V, Triaca V, Petrella C, Maruyama IN, Levi A, Calissano P. Canu N, et al. Among authors: pellegrino m. Front Mol Neurosci. 2017 Jan 31;10:15. doi: 10.3389/fnmol.2017.00015. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28197073 Free PMC article.
819 results