Morcos PN - Search Results

1

Pharmacokinetic/Pharmacodynamic predictors of clinical potency for hepatitis C virus nonnucleoside polymerase and protease inhibitors.

Reddy MB, Morcos PN, Le Pogam S, Ou Y, Frank K, Lave T, Smith P. Reddy MB, et al. Among authors: morcos pn. Antimicrob Agents Chemother. 2012 Jun;56(6):3144-56. doi: 10.1128/AAC.06283-11. Epub 2012 Apr 2. Antimicrob Agents Chemother. 2012. PMID: 22470110 Free PMC article.

2

Efficacy and safety of danoprevir-ritonavir plus peginterferon alfa-2a-ribavirin in hepatitis C virus genotype 1 prior null responders.

Gane EJ, Rouzier R, Wiercinska-Drapalo A, Larrey DG, Morcos PN, Brennan BJ, Le Pogam S, Nájera I, Petric R, Tran JQ, Kulkarni R, Zhang Y, Smith P, Yetzer ES, Shulman NS. Gane EJ, et al. Among authors: morcos pn. Antimicrob Agents Chemother. 2014;58(2):1136-45. doi: 10.1128/AAC.01515-13. Epub 2013 Dec 2. Antimicrob Agents Chemother. 2014. PMID: 24295986 Free PMC article. Clinical Trial.

3

A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail.

Morcos PN, Chang L, Kulkarni R, Giraudon M, Shulman N, Brennan BJ, Smith PF, Tran JQ. Morcos PN, et al. Eur J Clin Pharmacol. 2013 Nov;69(11):1939-49. doi: 10.1007/s00228-013-1556-y. Epub 2013 Jul 20. Eur J Clin Pharmacol. 2013. PMID: 23872824 Clinical Trial.

4

Effect of ritonavir-boosted danoprevir, a potent hepatitis C virus protease inhibitor, on the pharmacokinetics of methadone in healthy subjects undergoing methadone maintenance therapy.

Moreira SA, Morcos PN, Navarro MT, Bech N, Smith PF, Brennan BJ. Moreira SA, et al. Among authors: morcos pn. Pharmacotherapy. 2014 Mar;34(3):220-6. doi: 10.1002/phar.1341. Epub 2013 Aug 14. Pharmacotherapy. 2014. PMID: 23946152 Clinical Trial.

5

Characterization of the transmembrane transport and absolute bioavailability of the HCV protease inhibitor danoprevir.

Brennan BJ, Poirier A, Moreira S, Morcos PN, Goelzer P, Portmann R, Asthappan J, Funk C, Smith PF. Brennan BJ, et al. Among authors: morcos pn. Clin Pharmacokinet. 2015 May;54(5):537-49. doi: 10.1007/s40262-014-0222-6. Clin Pharmacokinet. 2015. PMID: 25488594

6

Pharmacokinetics of a three-way drug interaction between danoprevir, ritonavir and the organic anion transporting polypeptide (OATP) inhibitor ciclosporin.

Brennan BJ, Moreira SA, Morcos PN, Navarro MT, Asthappan J, Goelzer P, Weigl P, Smith PF. Brennan BJ, et al. Among authors: morcos pn. Clin Pharmacokinet. 2013 Sep;52(9):805-13. doi: 10.1007/s40262-013-0077-2. Clin Pharmacokinet. 2013. PMID: 23712757 Clinical Trial.

7

Ritonavir-boosted danoprevir-based regimens in treatment-naive and prior null responders with HCV genotype 1 or 4 and compensated cirrhosis.

Gane EJ, Rouzier R, Hassanein T, Stedman CA, Mazur W, Kupcova V, Le Pogam S, Eng S, Voulgari A, Morcos PN, Brennan BJ, Scalori A, Thommes J. Gane EJ, et al. Among authors: morcos pn. Hepatol Int. 2016 May;10(3):478-87. doi: 10.1007/s12072-015-9699-9. Epub 2016 Feb 17. Hepatol Int. 2016. PMID: 26886127 Clinical Trial.

8

Physiological modeling and assessments of regional drug bioavailability of danoprevir to determine whether a controlled release formulation is feasible.

Reddy MB, Connor A, Brennan BJ, Morcos PN, Zhou A, McLawhon P, Fretland A, Evans P, Smith P, Tran JQ. Reddy MB, et al. Among authors: morcos pn. Biopharm Drug Dispos. 2011 Jul;32(5):261-75. doi: 10.1002/bdd.756. Epub 2011 Jun 9. Biopharm Drug Dispos. 2011. PMID: 21660978 Clinical Trial.

9

Influence of chronic hepatitis C infection on cytochrome P450 3A4 activity using midazolam as an in vivo probe substrate.

Morcos PN, Moreira SA, Brennan BJ, Blotner S, Shulman NS, Smith PF. Morcos PN, et al. Eur J Clin Pharmacol. 2013 Oct;69(10):1777-84. doi: 10.1007/s00228-013-1525-5. Epub 2013 Jun 14. Eur J Clin Pharmacol. 2013. PMID: 23765407 Clinical Trial.

10

Effect of meal and antisecretory agents on the pharmacokinetics of danoprevir/ritonavir in healthy volunteers.

Morcos PN, Moreira SA, Navarro MT, Bech N, Quatkemeyer A, Smith PF, Brennan BJ. Morcos PN, et al. J Pharm Pharmacol. 2014 Jan;66(1):23-31. doi: 10.1111/jphp.12151. Epub 2013 Oct 10. J Pharm Pharmacol. 2014. PMID: 24117531 Clinical Trial.

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