Qin H - Search Results

1

Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor.

Lamberto I, Qin H, Noberini R, Premkumar L, Bourgin C, Riedl SJ, Song J, Pasquale EB. Lamberto I, et al. Among authors: qin h. Biochem J. 2012 Jul 1;445(1):47-56. doi: 10.1042/BJ20120408. Biochem J. 2012. PMID: 22489865 Free PMC article.

2

A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors.

Noberini R, De SK, Zhang Z, Wu B, Raveendra-Panickar D, Chen V, Vazquez J, Qin H, Song J, Cosford ND, Pellecchia M, Pasquale EB. Noberini R, et al. Among authors: qin h. Chem Biol Drug Des. 2011 Oct;78(4):667-78. doi: 10.1111/j.1747-0285.2011.01199.x. Epub 2011 Sep 6. Chem Biol Drug Des. 2011. PMID: 21791013 Free PMC article.

3

Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor.

Qin H, Shi J, Noberini R, Pasquale EB, Song J. Qin H, et al. J Biol Chem. 2008 Oct 24;283(43):29473-84. doi: 10.1074/jbc.M804114200. Epub 2008 Aug 14. J Biol Chem. 2008. PMID: 18708347 Free PMC article.

4

Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity.

Qin H, Noberini R, Huan X, Shi J, Pasquale EB, Song J. Qin H, et al. J Biol Chem. 2010 Jan 1;285(1):644-54. doi: 10.1074/jbc.M109.064824. Epub 2009 Oct 29. J Biol Chem. 2010. PMID: 19875447 Free PMC article.

5

Dynamic principle for designing antagonistic/agonistic molecules for EphA4 receptor, the only known ALS modifier.

Qin H, Lim LZ, Song J. Qin H, et al. ACS Chem Biol. 2015 Feb 20;10(2):372-8. doi: 10.1021/cb500413n. Epub 2014 Oct 24. ACS Chem Biol. 2015. PMID: 25334011

6

NMR studies reveal a novel mode for hFADD to bind with the unstructured hRTN3 which initiates the ER-stress activated apoptosis.

Liu J, Zhu W, Qin H, Song J. Liu J, et al. Among authors: qin h. Biochem Biophys Res Commun. 2009 Jun 12;383(4):433-9. doi: 10.1016/j.bbrc.2009.04.024. Epub 2009 Apr 11. Biochem Biophys Res Commun. 2009. PMID: 19364499

7

ALS-causing P56S mutation and splicing variation on the hVAPB MSP domain transform its β-sandwich fold into lipid-interacting helical conformations.

Qin H, Wang W, Song J. Qin H, et al. Biochem Biophys Res Commun. 2013 Feb 15;431(3):398-403. doi: 10.1016/j.bbrc.2013.01.039. Epub 2013 Jan 16. Biochem Biophys Res Commun. 2013. PMID: 23333387

8

Unique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulations.

Huan X, Shi J, Lim L, Mitra S, Zhu W, Qin H, Pasquale EB, Song J. Huan X, et al. Among authors: qin h. PLoS One. 2013 Sep 24;8(9):e74040. doi: 10.1371/journal.pone.0074040. eCollection 2013. PLoS One. 2013. PMID: 24086308 Free PMC article.

9

Rational design, solution conformation and identification of functional residues of the soluble and structured Nogo-54, which mimics Nogo-66 in inhibiting the CNS neurite outgrowth.

Li M, Li Y, Liao X, Liu J, Qin H, Xiao ZC, Song J. Li M, et al. Among authors: qin h. Biochem Biophys Res Commun. 2008 Sep 5;373(4):498-503. doi: 10.1016/j.bbrc.2008.06.052. Epub 2008 Jun 26. Biochem Biophys Res Commun. 2008. PMID: 18585367

10

Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations.

Qin H, Lim L, Song J. Qin H, et al. BMC Biophys. 2012 Jan 25;5:2. doi: 10.1186/2046-1682-5-2. BMC Biophys. 2012. PMID: 22277260 Free PMC article.

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