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Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
St Amour CV, Sansó M, Bösken CA, Lee KM, Larochelle S, Zhang C, Shokat KM, Geyer M, Fisher RP. St Amour CV, et al. Among authors: bosken ca. Mol Cell Biol. 2012 Jul;32(13):2372-83. doi: 10.1128/MCB.06657-11. Epub 2012 Apr 16. Mol Cell Biol. 2012. PMID: 22508988 Free PMC article.
The structure and substrate specificity of human Cdk12/Cyclin K.
Bösken CA, Farnung L, Hintermair C, Merzel Schachter M, Vogel-Bachmayr K, Blazek D, Anand K, Fisher RP, Eick D, Geyer M. Bösken CA, et al. Nat Commun. 2014 Mar 24;5:3505. doi: 10.1038/ncomms4505. Nat Commun. 2014. PMID: 24662513 Free PMC article.
Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation.
Itzen F, Greifenberg AK, Bösken CA, Geyer M. Itzen F, et al. Among authors: bosken ca. Nucleic Acids Res. 2014 Jul;42(12):7577-90. doi: 10.1093/nar/gku449. Epub 2014 May 23. Nucleic Acids Res. 2014. PMID: 24860166 Free PMC article.
Structural and Functional Analysis of the Cdk13/Cyclin K Complex.
Greifenberg AK, Hönig D, Pilarova K, Düster R, Bartholomeeusen K, Bösken CA, Anand K, Blazek D, Geyer M. Greifenberg AK, et al. Among authors: bosken ca. Cell Rep. 2016 Jan 12;14(2):320-31. doi: 10.1016/j.celrep.2015.12.025. Epub 2015 Dec 31. Cell Rep. 2016. PMID: 26748711 Free article.