Winton DJ - Search Results

1

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

Wilson CH, Crombie C, van der Weyden L, Poulogiannis G, Rust AG, Pardo M, Gracia T, Yu L, Choudhary J, Poulin GB, McIntyre RE, Winton DJ, March HN, Arends MJ, Fraser AG, Adams DJ. Wilson CH, et al. Among authors: winton dj. EMBO J. 2012 May 30;31(11):2486-97. doi: 10.1038/emboj.2012.91. Epub 2012 Apr 17. EMBO J. 2012. PMID: 22510880 Free PMC article.

2

Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.

Luo F, Brooks DG, Ye H, Hamoudi R, Poulogiannis G, Patek CE, Winton DJ, Arends MJ. Luo F, et al. Among authors: winton dj. Oncogene. 2007 Jun 28;26(30):4415-27. doi: 10.1038/sj.onc.1210231. Epub 2007 Feb 5. Oncogene. 2007. PMID: 17297472

3

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.

Luo F, Brooks DG, Ye H, Hamoudi R, Poulogiannis G, Patek CE, Winton DJ, Arends MJ. Luo F, et al. Among authors: winton dj. Int J Exp Pathol. 2009 Oct;90(5):558-74. doi: 10.1111/j.1365-2613.2009.00667.x. Int J Exp Pathol. 2009. PMID: 19765110 Free PMC article.

4

mTOR regulation by JNK: rescuing the starving intestinal cancer cell?

March HN, Winton DJ. March HN, et al. Among authors: winton dj. Gastroenterology. 2011 May;140(5):1387-91. doi: 10.1053/j.gastro.2011.03.027. Epub 2011 Mar 25. Gastroenterology. 2011. PMID: 21440581 No abstract available.

5

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis.

March HN, Rust AG, Wright NA, ten Hoeve J, de Ridder J, Eldridge M, van der Weyden L, Berns A, Gadiot J, Uren A, Kemp R, Arends MJ, Wessels LF, Winton DJ, Adams DJ. March HN, et al. Among authors: winton dj. Nat Genet. 2011 Nov 6;43(12):1202-9. doi: 10.1038/ng.990. Nat Genet. 2011. PMID: 22057237 Free PMC article.

6

Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis.

Sadien ID, Adler S, Mehmed S, Bailey S, Sawle A, Couturier DL, Eldridge M, Adams DJ, Kemp R, Lourenço FC, Winton DJ. Sadien ID, et al. Among authors: winton dj. Nature. 2024 Oct;634(8036):1196-1203. doi: 10.1038/s41586-024-08053-0. Epub 2024 Oct 30. Nature. 2024. PMID: 39478206 Free PMC article.

7

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.

Toft NJ, Winton DJ, Kelly J, Howard LA, Dekker M, te Riele H, Arends MJ, Wyllie AH, Margison GP, Clarke AR. Toft NJ, et al. Among authors: winton dj. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3911-5. doi: 10.1073/pnas.96.7.3911. Proc Natl Acad Sci U S A. 1999. PMID: 10097137 Free PMC article.

8

In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine.

Toft NJ, Sansom OJ, Brookes RA, Arends MJ, Wood M, Margison GP, Winton DJ, Clarke AR. Toft NJ, et al. Among authors: winton dj. Carcinogenesis. 2000 Apr;21(4):593-8. doi: 10.1093/carcin/21.4.593. Carcinogenesis. 2000. PMID: 10753191

9

A single type of progenitor cell maintains normal epidermis.

Clayton E, Doupé DP, Klein AM, Winton DJ, Simons BD, Jones PH. Clayton E, et al. Among authors: winton dj. Nature. 2007 Mar 8;446(7132):185-9. doi: 10.1038/nature05574. Epub 2007 Feb 28. Nature. 2007. PMID: 17330052

10

Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.

Mieszczanek J, van Tienen LM, Ibrahim AEK, Winton DJ, Bienz M. Mieszczanek J, et al. Among authors: winton dj. Nat Commun. 2019 Feb 13;10(1):724. doi: 10.1038/s41467-018-08164-z. Nat Commun. 2019. PMID: 30760710 Free PMC article.

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