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Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination.
Abdulrahman RM, Verloop H, Hoftijzer H, Verburg E, Hovens GC, Corssmit EP, Reiners C, Gelderblom H, Pereira AM, Kapiteijn E, Romijn JA, Visser TJ, Smit JW. Abdulrahman RM, et al. Among authors: verloop h. J Clin Endocrinol Metab. 2010 Aug;95(8):3758-62. doi: 10.1210/jc.2009-2507. Epub 2010 May 19. J Clin Endocrinol Metab. 2010. PMID: 20484486 Clinical Trial.