Lehmann J - Search Results

1

Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.

Chen Y, Sun J, Fang L, Liu M, Peng S, Liao H, Lehmann J, Zhang Y. Chen Y, et al. Among authors: lehmann j. J Med Chem. 2012 May 10;55(9):4309-21. doi: 10.1021/jm300106z. Epub 2012 Apr 27. J Med Chem. 2012. PMID: 22512543

2

Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.

Fang L, Appenroth D, Decker M, Kiehntopf M, Roegler C, Deufel T, Fleck C, Peng S, Zhang Y, Lehmann J. Fang L, et al. Among authors: lehmann j. J Med Chem. 2008 Feb 28;51(4):713-6. doi: 10.1021/jm701491k. Epub 2008 Jan 31. J Med Chem. 2008. PMID: 18232655

3

Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.

Fang L, Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M. Fang L, et al. Among authors: lehmann j. Bioorg Med Chem Lett. 2008 May 1;18(9):2905-9. doi: 10.1016/j.bmcl.2008.03.073. Epub 2008 Mar 30. Bioorg Med Chem Lett. 2008. PMID: 18406135

4

NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity.

Fang L, Appenroth D, Decker M, Kiehntopf M, Lupp A, Peng S, Fleck C, Zhang Y, Lehmann J. Fang L, et al. Among authors: lehmann j. J Med Chem. 2008 Dec 25;51(24):7666-9. doi: 10.1021/jm801131a. J Med Chem. 2008. PMID: 19053746

5

Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques.

Chen Y, Fang L, Peng S, Liao H, Lehmann J, Zhang Y. Chen Y, et al. Among authors: lehmann j. Bioorg Med Chem Lett. 2012 May 1;22(9):3181-7. doi: 10.1016/j.bmcl.2012.03.046. Epub 2012 Mar 16. Bioorg Med Chem Lett. 2012. PMID: 22472693

6

Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents.

Chen Y, Sun J, Huang Z, Liao H, Peng S, Lehmann J, Zhang Y. Chen Y, et al. Among authors: lehmann j. Bioorg Med Chem. 2013 May 1;21(9):2462-70. doi: 10.1016/j.bmc.2013.03.005. Epub 2013 Mar 13. Bioorg Med Chem. 2013. PMID: 23541836

7

NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity.

Chen Y, Sun J, Huang Z, Liao H, Peng S, Lehmann J, Zhang Y. Chen Y, et al. Among authors: lehmann j. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3162-5. doi: 10.1016/j.bmcl.2013.04.008. Epub 2013 Apr 10. Bioorg Med Chem Lett. 2013. PMID: 23639542

8

Tacrine-flurbiprofen hybrids as multifunctional drug candidates for the treatment of Alzheimer's disease.

Chen Y, Sun J, Peng S, Liao H, Zhang Y, Lehmann J. Chen Y, et al. Among authors: lehmann j. Arch Pharm (Weinheim). 2013 Dec;346(12):865-71. doi: 10.1002/ardp.201300074. Epub 2013 Nov 6. Arch Pharm (Weinheim). 2013. PMID: 24203864

9

Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety.

Fang L, Zhang Y, Lehmann J, Wang Y, Ji H, Ding D. Fang L, et al. Among authors: lehmann j. Bioorg Med Chem Lett. 2007 Feb 15;17(4):1062-6. doi: 10.1016/j.bmcl.2006.11.018. Epub 2006 Nov 10. Bioorg Med Chem Lett. 2007. PMID: 17129724

10

WITHDRAWN: Design and synthesis of pivalic acid linked tacrine-NO donor hybrids as novel anti-Alzheimer drug candidates.

Fang L, Roegler C, Decker M, Zhang Y, Lehmann J. Fang L, et al. Among authors: lehmann j. Bioorg Med Chem Lett. 2009 Jun 26. doi: 10.1016/j.bmcl.2009.06.089. Online ahead of print. Bioorg Med Chem Lett. 2009. PMID: 19679473

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