Dunbar KL - Search Results

1

YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.

Dunbar KL, Melby JO, Mitchell DA. Dunbar KL, et al. Nat Chem Biol. 2012 Apr 22;8(6):569-75. doi: 10.1038/nchembio.944. Nat Chem Biol. 2012. PMID: 22522320 Free PMC article.

2

Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase.

Melby JO, Dunbar KL, Trinh NQ, Mitchell DA. Melby JO, et al. Among authors: dunbar kl. J Am Chem Soc. 2012 Mar 21;134(11):5309-16. doi: 10.1021/ja211675n. Epub 2012 Mar 8. J Am Chem Soc. 2012. PMID: 22401305 Free PMC article.

3

Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis.

Dunbar KL, Mitchell DA. Dunbar KL, et al. ACS Chem Biol. 2013 Mar 15;8(3):473-87. doi: 10.1021/cb3005325. Epub 2013 Jan 8. ACS Chem Biol. 2013. PMID: 23286465 Free PMC article. Review.

4

Insights into the mechanism of peptide cyclodehydrations achieved through the chemoenzymatic generation of amide derivatives.

Dunbar KL, Mitchell DA. Dunbar KL, et al. J Am Chem Soc. 2013 Jun 12;135(23):8692-701. doi: 10.1021/ja4029507. Epub 2013 May 30. J Am Chem Soc. 2013. PMID: 23721104 Free PMC article.

5

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis.

Dunbar KL, Chekan JR, Cox CL, Burkhart BJ, Nair SK, Mitchell DA. Dunbar KL, et al. Nat Chem Biol. 2014 Oct;10(10):823-9. doi: 10.1038/nchembio.1608. Epub 2014 Aug 17. Nat Chem Biol. 2014. PMID: 25129028 Free PMC article.

6

Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products.

Dunbar KL, Tietz JI, Cox CL, Burkhart BJ, Mitchell DA. Dunbar KL, et al. J Am Chem Soc. 2015 Jun 24;137(24):7672-7. doi: 10.1021/jacs.5b04682. Epub 2015 Jun 12. J Am Chem Soc. 2015. PMID: 26024319 Free PMC article.

7

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis.

Burkhart BJ, Hudson GA, Dunbar KL, Mitchell DA. Burkhart BJ, et al. Among authors: dunbar kl. Nat Chem Biol. 2015 Aug;11(8):564-70. doi: 10.1038/nchembio.1856. Epub 2015 Jul 13. Nat Chem Biol. 2015. PMID: 26167873 Free PMC article.

8

Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics.

Molohon KJ, Melby JO, Lee J, Evans BS, Dunbar KL, Bumpus SB, Kelleher NL, Mitchell DA. Molohon KJ, et al. Among authors: dunbar kl. ACS Chem Biol. 2011 Dec 16;6(12):1307-13. doi: 10.1021/cb200339d. Epub 2011 Oct 6. ACS Chem Biol. 2011. PMID: 21950656 Free PMC article.

9

Reconstitution of Iterative Thioamidation in Closthioamide Biosynthesis Reveals Tailoring Strategy for Nonribosomal Peptide Backbones.

Dunbar KL, Dell M, Molloy EM, Kloss F, Hertweck C. Dunbar KL, et al. Angew Chem Int Ed Engl. 2019 Sep 9;58(37):13014-13018. doi: 10.1002/anie.201905992. Epub 2019 Aug 7. Angew Chem Int Ed Engl. 2019. PMID: 31276268 Free PMC article.

10

Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy.

Dunbar KL, Dell M, Gude F, Hertweck C. Dunbar KL, et al. Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):8850-8858. doi: 10.1073/pnas.1918759117. Epub 2020 Apr 7. Proc Natl Acad Sci U S A. 2020. PMID: 32265283 Free PMC article.

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