Mitchell DA - Search Results

1

YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.

Dunbar KL, Melby JO, Mitchell DA. Dunbar KL, et al. Among authors: mitchell da. Nat Chem Biol. 2012 Apr 22;8(6):569-75. doi: 10.1038/nchembio.944. Nat Chem Biol. 2012. PMID: 22522320 Free PMC article.

2

Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates.

Melby JO, Nard NJ, Mitchell DA. Melby JO, et al. Among authors: mitchell da. Curr Opin Chem Biol. 2011 Jun;15(3):369-78. doi: 10.1016/j.cbpa.2011.02.027. Epub 2011 Mar 21. Curr Opin Chem Biol. 2011. PMID: 21429787 Free PMC article. Review.

3

Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics.

Molohon KJ, Melby JO, Lee J, Evans BS, Dunbar KL, Bumpus SB, Kelleher NL, Mitchell DA. Molohon KJ, et al. Among authors: mitchell da. ACS Chem Biol. 2011 Dec 16;6(12):1307-13. doi: 10.1021/cb200339d. Epub 2011 Oct 6. ACS Chem Biol. 2011. PMID: 21950656 Free PMC article.

4

Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase.

Melby JO, Dunbar KL, Trinh NQ, Mitchell DA. Melby JO, et al. Among authors: mitchell da. J Am Chem Soc. 2012 Mar 21;134(11):5309-16. doi: 10.1021/ja211675n. Epub 2012 Mar 8. J Am Chem Soc. 2012. PMID: 22401305 Free PMC article.

5

Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis.

Dunbar KL, Mitchell DA. Dunbar KL, et al. Among authors: mitchell da. ACS Chem Biol. 2013 Mar 15;8(3):473-87. doi: 10.1021/cb3005325. Epub 2013 Jan 8. ACS Chem Biol. 2013. PMID: 23286465 Free PMC article. Review.

6

Insights into the mechanism of peptide cyclodehydrations achieved through the chemoenzymatic generation of amide derivatives.

Dunbar KL, Mitchell DA. Dunbar KL, et al. Among authors: mitchell da. J Am Chem Soc. 2013 Jun 12;135(23):8692-701. doi: 10.1021/ja4029507. Epub 2013 May 30. J Am Chem Soc. 2013. PMID: 23721104 Free PMC article.

7

Engineering unnatural variants of plantazolicin through codon reprogramming.

Deane CD, Melby JO, Molohon KJ, Susarrey AR, Mitchell DA. Deane CD, et al. Among authors: mitchell da. ACS Chem Biol. 2013 Sep 20;8(9):1998-2008. doi: 10.1021/cb4003392. Epub 2013 Jul 3. ACS Chem Biol. 2013. PMID: 23823732 Free PMC article.

8

Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis.

Lee J, Hao Y, Blair PM, Melby JO, Agarwal V, Burkhart BJ, Nair SK, Mitchell DA. Lee J, et al. Among authors: mitchell da. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12954-9. doi: 10.1073/pnas.1306101110. Epub 2013 Jul 22. Proc Natl Acad Sci U S A. 2013. PMID: 23878226 Free PMC article.

9

Synthesis of plantazolicin analogues enables dissection of ligand binding interactions of a highly selective methyltransferase.

Sharma A, Saint-Vincent PMB, Mitchell DA. Sharma A, et al. Among authors: mitchell da. Org Lett. 2013 Oct 4;15(19):5076-9. doi: 10.1021/ol402444a. Epub 2013 Sep 24. Org Lett. 2013. PMID: 24063702 Free PMC article.

10

Orchestration of enzymatic processing by thiazole/oxazole-modified microcin dehydrogenases.

Melby JO, Li X, Mitchell DA. Melby JO, et al. Among authors: mitchell da. Biochemistry. 2014 Jan 21;53(2):413-22. doi: 10.1021/bi401529y. Epub 2014 Jan 7. Biochemistry. 2014. PMID: 24364559 Free PMC article.

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