McCafferty DG - Search Results

1

Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.

Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Pollock JA, et al. Among authors: mccafferty dg. ACS Chem Biol. 2012 Jul 20;7(7):1221-31. doi: 10.1021/cb300108c. Epub 2012 May 10. ACS Chem Biol. 2012. PMID: 22533360 Free PMC article.

2

Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.

Gooden DM, Schmidt DM, Pollock JA, Kabadi AM, McCafferty DG. Gooden DM, et al. Among authors: mccafferty dg. Bioorg Med Chem Lett. 2008 May 15;18(10):3047-51. doi: 10.1016/j.bmcl.2008.01.003. Epub 2008 Jan 8. Bioorg Med Chem Lett. 2008. PMID: 18242989 Free PMC article.

3

KDM1 class flavin-dependent protein lysine demethylases.

Burg JM, Link JE, Morgan BS, Heller FJ, Hargrove AE, McCafferty DG. Burg JM, et al. Among authors: mccafferty dg. Biopolymers. 2015 Jul;104(4):213-46. doi: 10.1002/bip.22643. Biopolymers. 2015. PMID: 25787087 Free PMC article. Review.

4

Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones.

Burg JM, Gonzalez JJ, Maksimchuk KR, McCafferty DG. Burg JM, et al. Among authors: mccafferty dg. Biochemistry. 2016 Mar 22;55(11):1652-62. doi: 10.1021/acs.biochem.5b01135. Epub 2016 Feb 9. Biochemistry. 2016. PMID: 26673564 Free PMC article.

5

trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

Schmidt DM, McCafferty DG. Schmidt DM, et al. Among authors: mccafferty dg. Biochemistry. 2007 Apr 10;46(14):4408-16. doi: 10.1021/bi0618621. Epub 2007 Mar 17. Biochemistry. 2007. PMID: 17367163

6

Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST.

Hwang S, Schmitt AA, Luteran AE, Toone EJ, McCafferty DG. Hwang S, et al. Among authors: mccafferty dg. Biochemistry. 2011 Feb 1;50(4):546-57. doi: 10.1021/bi101776t. Epub 2010 Dec 30. Biochemistry. 2011. PMID: 21142040 Free PMC article.

7

Crossing a biological velvet rope.

McCafferty DG. McCafferty DG. ACS Chem Biol. 2006 Jul 21;1(6):339-40. doi: 10.1021/cb6002948. ACS Chem Biol. 2006. PMID: 17163767 Review.

8

A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity.

Burg JM, Makhoul AT, Pemble CW 4th, Link JE, Heller FJ, McCafferty DG. Burg JM, et al. Among authors: mccafferty dg. FEBS Lett. 2015 Aug 19;589(18):2340-6. doi: 10.1016/j.febslet.2015.07.028. Epub 2015 Jul 29. FEBS Lett. 2015. PMID: 26226427 Free PMC article.

9

Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration.

Hatstat AK, Pupi MD, Reinhart MC, McCafferty DG. Hatstat AK, et al. Among authors: mccafferty dg. ACS Chem Neurosci. 2021 Nov 3;12(21):3972-3984. doi: 10.1021/acschemneuro.1c00524. Epub 2021 Oct 15. ACS Chem Neurosci. 2021. PMID: 34652126 Free PMC article.

10

Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade.

Hatstat AK, Ahrendt HD, Foster MW, Mayne L, Moseley MA, Englander SW, McCafferty DG. Hatstat AK, et al. Among authors: mccafferty dg. Cell Chem Biol. 2021 Jan 21;28(1):14-25.e9. doi: 10.1016/j.chembiol.2020.10.008. Epub 2020 Nov 10. Cell Chem Biol. 2021. PMID: 33176158 Free PMC article.

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