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Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.
Tennstaedt A, Pöpsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, Irle I, Sacca B, Niemeyer CM, Brandt R, Ksiezak-Reding H, Tirniceriu AL, Egensperger R, Baldi A, Dehmelt L, Kaiser M, Huber R, Clausen T, Ehrmann M. Tennstaedt A, et al. J Biol Chem. 2012 Jun 15;287(25):20931-41. doi: 10.1074/jbc.M111.316232. Epub 2012 Apr 25. J Biol Chem. 2012. PMID: 22535953 Free PMC article.
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.
Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G. Sinha S, et al. Among authors: tennstaedt a. J Am Chem Soc. 2011 Oct 26;133(42):16958-69. doi: 10.1021/ja206279b. Epub 2011 Sep 29. J Am Chem Soc. 2011. PMID: 21916458 Free PMC article.
13 results