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An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor β receptor.
Hoyles RK, Derrett-Smith EC, Khan K, Shiwen X, Howat SL, Wells AU, Abraham DJ, Denton CP. Hoyles RK, et al. Among authors: howat sl. Am J Respir Crit Care Med. 2011 Jan 15;183(2):249-61. doi: 10.1164/rccm.201002-0279OC. Epub 2010 Aug 13. Am J Respir Crit Care Med. 2011. PMID: 20709822
Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
Renzoni EA, Abraham DJ, Howat S, Shi-Wen X, Sestini P, Bou-Gharios G, Wells AU, Veeraraghavan S, Nicholson AG, Denton CP, Leask A, Pearson JD, Black CM, Welsh KI, du Bois RM. Renzoni EA, et al. Among authors: howat s. Respir Res. 2004 Nov 30;5(1):24. doi: 10.1186/1465-9921-5-24. Respir Res. 2004. PMID: 15571627 Free PMC article.
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
Shi-Wen X, Rodríguez-Pascual F, Lamas S, Holmes A, Howat S, Pearson JD, Dashwood MR, du Bois RM, Denton CP, Black CM, Abraham DJ, Leask A. Shi-Wen X, et al. Among authors: howat s. Mol Cell Biol. 2006 Jul;26(14):5518-27. doi: 10.1128/MCB.00625-06. Mol Cell Biol. 2006. PMID: 16809784 Free PMC article.
Fibroblast-specific perturbation of transforming growth factor beta signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis: exaggerated response to alveolar epithelial injury in a novel mouse model.
Hoyles RK, Khan K, Shiwen X, Howat SL, Lindahl GE, Leoni P, du Bois RM, Wells AU, Black CM, Abraham DJ, Denton CP. Hoyles RK, et al. Among authors: howat sl. Arthritis Rheum. 2008 Apr;58(4):1175-88. doi: 10.1002/art.23379. Arthritis Rheum. 2008. PMID: 18383385 Free article.
Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease.
Lindahl GE, Stock CJ, Shi-Wen X, Leoni P, Sestini P, Howat SL, Bou-Gharios G, Nicholson AG, Denton CP, Grutters JC, Maher TM, Wells AU, Abraham DJ, Renzoni EA. Lindahl GE, et al. Among authors: howat sl. Respir Res. 2013 Aug 2;14(1):80. doi: 10.1186/1465-9921-14-80. Respir Res. 2013. PMID: 23915349 Free PMC article.
18 results