Li J - Search Results

1

Discovery of XL413, a potent and selective CDC7 inhibitor.

Koltun ES, Tsuhako AL, Brown DS, Aay N, Arcalas A, Chan V, Du H, Engst S, Ferguson K, Franzini M, Galan A, Holst CR, Huang P, Kane B, Kim MH, Li J, Markby D, Mohan M, Noson K, Plonowski A, Richards SJ, Robertson S, Shaw K, Stott G, Stout TJ, Young J, Yu P, Zaharia CA, Zhang W, Zhou P, Nuss JM, Xu W, Kearney PC. Koltun ES, et al. Among authors: li j. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. doi: 10.1016/j.bmcl.2012.04.024. Epub 2012 Apr 16. Bioorg Med Chem Lett. 2012. PMID: 22560567

2

Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface.

Ren J, Xu W, Tang L, Su M, Chen D, Chen YL, Zang Y, Li J, Shen J, Zhou Y, Xiong B. Ren J, et al. Among authors: li j. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4472-4476. doi: 10.1016/j.bmcl.2016.07.074. Epub 2016 Aug 2. Bioorg Med Chem Lett. 2016. PMID: 27528435

3

Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors.

Zhang J, Gao L, Xi J, Sheng L, Zhao Y, Xu L, Shao Y, Liu S, Zhuang R, Zhou Y, Li J. Zhang J, et al. Among authors: li j. Bioorg Med Chem. 2016 Dec 1;24(23):6206-6214. doi: 10.1016/j.bmc.2016.10.002. Epub 2016 Oct 6. Bioorg Med Chem. 2016. PMID: 27765408

4

Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis.

Wang S, Xu L, Lu YT, Liu YF, Han B, Liu T, Tang J, Li J, Wu J, Li JY, Yu LF, Yang F. Wang S, et al. Among authors: li jy, li j. Eur J Med Chem. 2017 Apr 21;130:195-208. doi: 10.1016/j.ejmech.2017.02.048. Epub 2017 Feb 21. Eur J Med Chem. 2017. PMID: 28249207

5

Nitric oxide-releasing derivatives of brefeldin A as potent and highly selective anticancer agents.

Tian K, Xu F, Gao X, Han T, Li J, Pan H, Zang L, Li D, Li Z, Uchita T, Gao M, Hua H. Tian K, et al. Among authors: li d, li j, li z. Eur J Med Chem. 2017 Aug 18;136:131-143. doi: 10.1016/j.ejmech.2017.05.018. Epub 2017 May 5. Eur J Med Chem. 2017. PMID: 28494251

6

Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.

Wang WL, Chen XY, Gao Y, Gao LX, Sheng L, Zhu J, Xu L, Ding ZZ, Zhang C, Li JY, Li J, Zhou YB. Wang WL, et al. Among authors: li jy, li j. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5154-5157. doi: 10.1016/j.bmcl.2017.10.059. Epub 2017 Oct 26. Bioorg Med Chem Lett. 2017. PMID: 29100798

7

Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors.

Sun L, Wang P, Xu L, Gao L, Li J, Piao H. Sun L, et al. Among authors: li j. Bioorg Med Chem Lett. 2019 May 15;29(10):1187-1193. doi: 10.1016/j.bmcl.2019.03.023. Epub 2019 Mar 20. Bioorg Med Chem Lett. 2019. PMID: 30910462

8

Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies.

Tong L, Song P, Jiang K, Xu L, Jin T, Wang P, Hu X, Fang S, Gao A, Zhou Y, Liu T, Li J, Hu Y. Tong L, et al. Among authors: li j. Eur J Med Chem. 2019 Jul 1;173:44-62. doi: 10.1016/j.ejmech.2019.03.062. Epub 2019 Apr 3. Eur J Med Chem. 2019. PMID: 30986571

9

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design.

Dong X, Zhan W, Zhao M, Che J, Dai X, Wu Y, Xu L, Zhou Y, Zhao Y, Tian T, Cheng G, Jin Z, Li J, Shao Y, He Q, Yang B, Weng Q, Hu Y. Dong X, et al. Among authors: li j. J Med Chem. 2019 Aug 8;62(15):7264-7288. doi: 10.1021/acs.jmedchem.9b00891. Epub 2019 Jul 24. J Med Chem. 2019. PMID: 31298542

10

Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors.

Zhan W, Che J, Xu L, Wu Y, Hu X, Zhou Y, Cheng G, Hu Y, Dong X, Li J. Zhan W, et al. Among authors: li j. Eur J Med Chem. 2019 Oct 15;180:72-85. doi: 10.1016/j.ejmech.2019.07.017. Epub 2019 Jul 7. Eur J Med Chem. 2019. PMID: 31301565

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