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Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P. Al-Hasani K, et al. Among authors: gradwohl g. Dev Cell. 2013 Jul 15;26(1):86-100. doi: 10.1016/j.devcel.2013.05.018. Epub 2013 Jun 27. Dev Cell. 2013. PMID: 23810513 Free article.
Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production.
Piccand J, Vagne C, Blot F, Meunier A, Beucher A, Strasser P, Lund ML, Ghimire S, Nivlet L, Lapp C, Petersen N, Engelstoft MS, Thibault-Carpentier C, Keime C, Correa SJ, Schreiber V, Molina N, Schwartz TW, De Arcangelis A, Gradwohl G. Piccand J, et al. Among authors: gradwohl g. Mol Metab. 2019 Nov;29:24-39. doi: 10.1016/j.molmet.2019.08.007. Epub 2019 Aug 13. Mol Metab. 2019. PMID: 31668390 Free PMC article.
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network.
Schreiber V, Mercier R, Jiménez S, Ye T, García-Sánchez E, Klein A, Meunier A, Ghimire S, Birck C, Jost B, de Lichtenberg KH, Honoré C, Serup P, Gradwohl G. Schreiber V, et al. Among authors: gradwohl g. Mol Metab. 2021 Nov;53:101313. doi: 10.1016/j.molmet.2021.101313. Epub 2021 Aug 3. Mol Metab. 2021. PMID: 34352411 Free PMC article.
Opposing actions of Arx and Pax4 in endocrine pancreas development.
Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P. Collombat P, et al. Among authors: gradwohl g. Genes Dev. 2003 Oct 15;17(20):2591-603. doi: 10.1101/gad.269003. Genes Dev. 2003. PMID: 14561778 Free PMC article.
89 results