Bissantz C - Search Results

1

Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK₁/NK₃ antagonists.

Bissantz C, Bohnert C, Hoffmann T, Marcuz A, Schnider P, Malherbe P. Bissantz C, et al. J Med Chem. 2012 Jun 14;55(11):5061-76. doi: 10.1021/jm2017072. Epub 2012 May 22. J Med Chem. 2012. PMID: 22574973

2

From astemizole to a novel hit series of small-molecule somatostatin 5 receptor antagonists via GPCR affinity profiling.

Guba W, Green LG, Martin RE, Roche O, Kratochwil N, Mauser H, Bissantz C, Christ A, Stahl M. Guba W, et al. Among authors: bissantz c. J Med Chem. 2007 Dec 13;50(25):6295-8. doi: 10.1021/jm701144e. Epub 2007 Nov 19. J Med Chem. 2007. PMID: 18020391

3

Me-talnetant and osanetant interact within overlapping but not identical binding pockets in the human tachykinin neurokinin 3 receptor transmembrane domains.

Malherbe P, Bissantz C, Marcuz A, Kratzeisen C, Zenner MT, Wettstein JG, Ratni H, Riemer C, Spooren W. Malherbe P, et al. Among authors: bissantz c. Mol Pharmacol. 2008 Jun;73(6):1736-50. doi: 10.1124/mol.107.042754. Epub 2008 Feb 28. Mol Pharmacol. 2008. PMID: 18308898

4

Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures.

Malherbe P, Kratzeisen C, Marcuz A, Zenner MT, Nettekoven MH, Ratni H, Wettstein JG, Bissantz C. Malherbe P, et al. Among authors: bissantz c. J Med Chem. 2009 Nov 26;52(22):7103-12. doi: 10.1021/jm900948q. J Med Chem. 2009. PMID: 19817444

5

A medicinal chemist's guide to molecular interactions.

Bissantz C, Kuhn B, Stahl M. Bissantz C, et al. J Med Chem. 2010 Jul 22;53(14):5061-84. doi: 10.1021/jm100112j. J Med Chem. 2010. PMID: 20345171 Free PMC article. Review. No abstract available.

6

Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA).

Malherbe P, Roche O, Marcuz A, Kratzeisen C, Wettstein JG, Bissantz C. Malherbe P, et al. Among authors: bissantz c. Mol Pharmacol. 2010 Jul;78(1):81-93. doi: 10.1124/mol.110.064584. Epub 2010 Apr 19. Mol Pharmacol. 2010. PMID: 20404073

7

Rational design of novel pyrrolidine derivatives as orally active neurokinin-3 receptor antagonists.

Ratni H, Ballard TM, Bissantz C, Hoffmann T, Jablonski P, Knoflach F, Knust H, Malherbe P, Nettekoven M, Patiny-Adam A, Riemer C, Schmitt M, Spooren W. Ratni H, et al. Among authors: bissantz c. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6735-8. doi: 10.1016/j.bmcl.2010.08.138. Epub 2010 Sep 17. Bioorg Med Chem Lett. 2010. PMID: 20850972

8

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.

Dehmlow H, Alvarez Sánchez R, Bachmann S, Bissantz C, Bliss F, Conde-Knape K, Graf M, Martin RE, Obst Sander U, Raab S, Richter HG, Sewing S, Sprecher U, Ullmer C, Mattei P. Dehmlow H, et al. Among authors: bissantz c. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4627-32. doi: 10.1016/j.bmcl.2013.06.017. Epub 2013 Jun 19. Bioorg Med Chem Lett. 2013. PMID: 23831134

9

Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.

Malherbe P, Knoflach F, Marcuz A, Bohnert C, Weber M, Knust H, Ratni H, Spooren W, Ballard TM, Bissantz C. Malherbe P, et al. Among authors: bissantz c. Neuropharmacology. 2014 Nov;86:259-72. doi: 10.1016/j.neuropharm.2014.07.017. Epub 2014 Aug 5. Neuropharmacology. 2014. PMID: 25107588

10

Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach.

Ratni H, Rogers-Evans M, Bissantz C, Grundschober C, Moreau JL, Schuler F, Fischer H, Alvarez Sanchez R, Schnider P. Ratni H, et al. Among authors: bissantz c. J Med Chem. 2015 Mar 12;58(5):2275-89. doi: 10.1021/jm501745f. Epub 2015 Feb 18. J Med Chem. 2015. PMID: 25654260

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