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Page 1
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.
Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ. Rogers CS, et al. Among authors: uc a. Science. 2008 Sep 26;321(5897):1837-41. doi: 10.1126/science.1163600. Science. 2008. PMID: 18818360 Free PMC article.
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.
Stoltz DA, Meyerholz DK, Pezzulo AA, Ramachandran S, Rogan MP, Davis GJ, Hanfland RA, Wohlford-Lenane C, Dohrn CL, Bartlett JA, Nelson GA 4th, Chang EH, Taft PJ, Ludwig PS, Estin M, Hornick EE, Launspach JL, Samuel M, Rokhlina T, Karp PH, Ostedgaard LS, Uc A, Starner TD, Horswill AR, Brogden KA, Prather RS, Richter SS, Shilyansky J, McCray PB Jr, Zabner J, Welsh MJ. Stoltz DA, et al. Among authors: uc a. Sci Transl Med. 2010 Apr 28;2(29):29ra31. doi: 10.1126/scitranslmed.3000928. Sci Transl Med. 2010. PMID: 20427821 Free PMC article.
The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs.
Ostedgaard LS, Meyerholz DK, Chen JH, Pezzulo AA, Karp PH, Rokhlina T, Ernst SE, Hanfland RA, Reznikov LR, Ludwig PS, Rogan MP, Davis GJ, Dohrn CL, Wohlford-Lenane C, Taft PJ, Rector MV, Hornick E, Nassar BS, Samuel M, Zhang Y, Richter SS, Uc A, Shilyansky J, Prather RS, McCray PB Jr, Zabner J, Welsh MJ, Stoltz DA. Ostedgaard LS, et al. Among authors: uc a. Sci Transl Med. 2011 Mar 16;3(74):74ra24. doi: 10.1126/scitranslmed.3001868. Sci Transl Med. 2011. PMID: 21411740 Free PMC article.
Pancreatic and biliary secretion are both altered in cystic fibrosis pigs.
Uc A, Giriyappa R, Meyerholz DK, Griffin M, Ostedgaard LS, Tang XX, Abu-El-Haija M, Stoltz DA, Ludwig P, Pezzulo A, Abu-El-Haija M, Taft P, Welsh MJ. Uc A, et al. Am J Physiol Gastrointest Liver Physiol. 2012 Oct 15;303(8):G961-8. doi: 10.1152/ajpgi.00030.2012. Epub 2012 Aug 30. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 22936270 Free PMC article.
A novel gene delivery method transduces porcine pancreatic duct epithelial cells.
Griffin MA, Restrepo MS, Abu-El-Haija M, Wallen T, Buchanan E, Rokhlina T, Chen YH, McCray PB Jr, Davidson BL, Divekar A, Uc A. Griffin MA, et al. Among authors: uc a. Gene Ther. 2014 Feb;21(2):123-30. doi: 10.1038/gt.2013.62. Epub 2013 Nov 21. Gene Ther. 2014. PMID: 24257348 Free PMC article.
Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass.
Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, Norris AW. Uc A, et al. Clin Sci (Lond). 2015 Jan;128(2):131-42. doi: 10.1042/CS20140059. Clin Sci (Lond). 2015. PMID: 25142104 Free PMC article.
Toxic-metabolic Risk Factors in Pediatric Pancreatitis: Recommendations for Diagnosis, Management, and Future Research.
Husain SZ, Morinville V, Pohl J, Abu-El-Haija M, Bellin MD, Freedman S, Hegyi P, Heyman MB, Himes R, Ooi CY, Schwarzenberg SJ, Usatin D, Uc A. Husain SZ, et al. Among authors: uc a. J Pediatr Gastroenterol Nutr. 2016 Apr;62(4):609-17. doi: 10.1097/MPG.0000000000001035. J Pediatr Gastroenterol Nutr. 2016. PMID: 26594832 Free PMC article. Review.
114 results