Ross CA - Search Results

1

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.

Ratovitski T, Chighladze E, Arbez N, Boronina T, Herbrich S, Cole RN, Ross CA. Ratovitski T, et al. Among authors: ross ca. Cell Cycle. 2012 May 15;11(10):2006-21. doi: 10.4161/cc.20423. Epub 2012 May 15. Cell Cycle. 2012. PMID: 22580459 Free PMC article.

2

N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease.

Ratovitski T, Nakamura M, D'Ambola J, Chighladze E, Liang Y, Wang W, Graham R, Hayden MR, Borchelt DR, Hirschhorn RR, Ross CA. Ratovitski T, et al. Among authors: ross ca. Cell Cycle. 2007 Dec 1;6(23):2970-81. doi: 10.4161/cc.6.23.4992. Cell Cycle. 2007. PMID: 18156806

3

Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells.

Ratovitski T, Gucek M, Jiang H, Chighladze E, Waldron E, D'Ambola J, Hou Z, Liang Y, Poirier MA, Hirschhorn RR, Graham R, Hayden MR, Cole RN, Ross CA. Ratovitski T, et al. Among authors: ross ca. J Biol Chem. 2009 Apr 17;284(16):10855-67. doi: 10.1074/jbc.M804813200. Epub 2009 Feb 9. J Biol Chem. 2009. PMID: 19204007 Free PMC article.

4

Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin.

Ratovitski T, Chighladze E, Waldron E, Hirschhorn RR, Ross CA. Ratovitski T, et al. Among authors: ross ca. J Biol Chem. 2011 Apr 8;286(14):12578-89. doi: 10.1074/jbc.M110.185348. Epub 2011 Feb 10. J Biol Chem. 2011. PMID: 21310951 Free PMC article.

5

Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.

Watkin EE, Arbez N, Waldron-Roby E, O'Meally R, Ratovitski T, Cole RN, Ross CA. Watkin EE, et al. Among authors: ross ca. PLoS One. 2014 Feb 5;9(2):e88284. doi: 10.1371/journal.pone.0088284. eCollection 2014. PLoS One. 2014. PMID: 24505464 Free PMC article.

6

PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).

Ratovitski T, Arbez N, Stewart JC, Chighladze E, Ross CA. Ratovitski T, et al. Among authors: ross ca. Cell Cycle. 2015;14(11):1716-29. doi: 10.1080/15384101.2015.1033595. Cell Cycle. 2015. PMID: 25927346 Free PMC article.

7

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity.

Arbez N, Ratovitski T, Roby E, Chighladze E, Stewart JC, Ren M, Wang X, Lavery DJ, Ross CA. Arbez N, et al. Among authors: ross ca. J Biol Chem. 2017 Nov 24;292(47):19238-19249. doi: 10.1074/jbc.M117.782300. Epub 2017 Sep 27. J Biol Chem. 2017. PMID: 28972180 Free PMC article.

8

Interaction of huntingtin with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity.

Ratovitski T, Jiang M, O'Meally RN, Rauniyar P, Chighladze E, Faragó A, Kamath SV, Jin J, Shevelkin AV, Cole RN, Ross CA. Ratovitski T, et al. Among authors: ross ca. Hum Mol Genet. 2022 May 19;31(10):1651-1672. doi: 10.1093/hmg/ddab351. Hum Mol Genet. 2022. PMID: 34888656 Free PMC article.

9

pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model.

Xu X, Ng B, Sim B, Radulescu CI, Yusof NABM, Goh WI, Lin S, Lim JSY, Cha Y, Kusko R, Kay C, Ratovitski T, Ross C, Hayden MR, Wright G, Pouladi MA. Xu X, et al. Cell Death Dis. 2020 Sep 25;11(9):809. doi: 10.1038/s41419-020-02983-z. Cell Death Dis. 2020. PMID: 32978366 Free PMC article.

10

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line.

Liang Y, Jiang H, Ratovitski T, Jie C, Nakamura M, Hirschhorn RR, Wang X, Smith WW, Hai T, Poirier MA, Ross CA. Liang Y, et al. Among authors: ross ca. Brain Res. 2009 Aug 25;1286:221-9. doi: 10.1016/j.brainres.2009.06.049. Epub 2009 Jun 24. Brain Res. 2009. PMID: 19559011 Free PMC article.

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