O'Connor OA - Search Results

1

Development and characterization of a novel CD19CherryLuciferase (CD19CL) transgenic mouse for the preclinical study of B-cell lymphomas.

Scotto L, Kruithof-de Julio M, Paoluzzi L, Kalac M, Marchi E, Buitrago JB, Amengual J, Shen MM, O'Connor OA. Scotto L, et al. Clin Cancer Res. 2012 Jul 15;18(14):3803-11. doi: 10.1158/1078-0432.CCR-11-2588. Epub 2012 May 15. Clin Cancer Res. 2012. PMID: 22589392

2

The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma.

Toner LE, Vrhovac R, Smith EA, Gardner J, Heaney M, Gonen M, Teruya-Feldstein J, Sirotnak F, O'Connor OA. Toner LE, et al. Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):924-32. doi: 10.1158/1078-0432.CCR-05-0331. Clin Cancer Res. 2006. PMID: 16467107

3

Mechanistic rationale and clinical evidence for the efficacy of proteasome inhibitors against indolent and mantle cell lymphomas.

Paoluzzi L, O'Connor OA. Paoluzzi L, et al. BioDrugs. 2006;20(1):13-23. doi: 10.2165/00063030-200620010-00002. BioDrugs. 2006. PMID: 16573348 Review.

4

The combination of the proteasome inhibitor bortezomib and the bcl-2 antisense molecule oblimersen sensitizes human B-cell lymphomas to cyclophosphamide.

O'Connor OA, Smith EA, Toner LE, Teruya-Feldstein J, Frankel S, Rolfe M, Wei X, Liu S, Marcucci G, Chan KK, Chanan-Khan A. O'Connor OA, et al. Clin Cancer Res. 2006 May 1;12(9):2902-11. doi: 10.1158/1078-0432.CCR-05-0308. Clin Cancer Res. 2006. PMID: 16675587

5

Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma.

Paoluzzi L, Gonen M, Gardner JR, Mastrella J, Yang D, Holmlund J, Sorensen M, Leopold L, Manova K, Marcucci G, Heaney ML, O'Connor OA. Paoluzzi L, et al. Blood. 2008 Jun 1;111(11):5350-8. doi: 10.1182/blood-2007-12-129833. Epub 2008 Feb 21. Blood. 2008. PMID: 18292288 Free article.

6

The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies.

Paoluzzi L, Gonen M, Bhagat G, Furman RR, Gardner JR, Scotto L, Gueorguiev VD, Heaney ML, Manova K, O'Connor OA. Paoluzzi L, et al. Blood. 2008 Oct 1;112(7):2906-16. doi: 10.1182/blood-2007-12-130781. Epub 2008 Jun 30. Blood. 2008. PMID: 18591385 Free article.

7

New drugs for the treatment of lymphoma.

Paoluzzi L, Kitagawa Y, Kalac M, Zain J, O'Connor OA. Paoluzzi L, et al. Hematol Oncol Clin North Am. 2008 Oct;22(5):1007-35, x. doi: 10.1016/j.hoc.2008.07.006. Hematol Oncol Clin North Am. 2008. PMID: 18954749 Review.

8

The anti-histaminic cyproheptadine synergizes the antineoplastic activity of bortezomib in mantle cell lymphoma through its effects as a histone deacetylase inhibitor.

Paoluzzi L, Scotto L, Marchi E, Seshan VE, O'Connor OA. Paoluzzi L, et al. Br J Haematol. 2009 Sep;146(6):656-9. doi: 10.1111/j.1365-2141.2009.07797.x. Epub 2009 Jul 8. Br J Haematol. 2009. PMID: 19604235 Free article.

9

Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma.

Paoluzzi L, Scotto L, Marchi E, Zain J, Seshan VE, O'Connor OA. Paoluzzi L, et al. Clin Cancer Res. 2010 Jan 15;16(2):554-65. doi: 10.1158/1078-0432.CCR-09-1937. Epub 2010 Jan 12. Clin Cancer Res. 2010. PMID: 20068080

10

Time to treatment response in patients with follicular lymphoma treated with bortezomib is longer compared with other histologic subtypes.

O'Connor OA, Portlock C, Moskowitz C, Hamlin P, Straus D, Gerecitano J, Gonen M, Dumitrescu O, Sarasohn D, Butos J, Neylon E, Mac-Gregor Cortelli B, Blumel S, Evens AM, Zelenetz AD, Wright J, Cooper B, Winter J, Vose J. O'Connor OA, et al. Clin Cancer Res. 2010 Jan 15;16(2):719-26. doi: 10.1158/1078-0432.CCR-08-2647. Epub 2010 Jan 12. Clin Cancer Res. 2010. PMID: 20068103 Clinical Trial.

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